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urea (Carmol 10, Keralac, Carmol 20, Carmol 40, Gordon's Urea, Aquacare, Ureacin 10, Ureacin 20, Utopic, Vanamide)

 

Classes: Emollients

Dosing and uses of Carmol 10, Keralac (urea)

 

Adult dosage forms and strengths

cream

  • 10%
  • 20%
  • 30%
  • 35%
  • 40%
  • 41%
  • 45%
  • 50%

lotion

  • 10%
  • 20%
  • 25%
  • 35%
  • 40%
  • 45%

geL

  • 40%
  • 45%
  • 50%

suspension

  • 40%
  • 50%

solution

  • 50%

ointment

  • 10%
  • 20%
  • 50%

emulsion

  • 40%
  • 45%
  • 50%

aerosol, foam

  • 20%
  • 30%
  • 35%
  • 40%
  • 42%

 

Hyperkeratotic Skin Conditions

Indicated for hyperkeratotic conditions such as dry, rough skin; xerosis; ichthyosis; skin cracks and fissures; dermatitis; eczema; psoriasis; keratoses; and calluses

Apply topically to affected skin qDay or q8-12hr

 

Administration

Rub lotion/cream into skin until completely absorbed

 

Pediatric dosage forms and strengths

Safety and efficacy not established

 

Carmol 10, Keralac (urea) adverse (side) effects

Frequency not defined

Local irritation

Transient stinging

Rash

 

Warnings

Contraindications

Hypersensitivity

Viral skin disease

 

Cautions

Ischemic skin necrosis reported with high concentration or irrigation

Not for use near the eye

 

Pregnancy and lactation

Pregnancy category: C

Lactation: Unknown

Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Carmol 10, Keralac (urea)

Mechanism of action

Elicits emollient and keratolytic effects; softens hyperkeratotic areas by disolving intracellular matrix, which subsequently loosens horny layer of the skin, or softens and debrides the nail plate