urea (Carmol 10, Keralac, Carmol 20, Carmol 40, Gordon's Urea, Aquacare, Ureacin 10, Ureacin 20, Utopic, Vanamide)
Classes: Emollients
Dosing and uses of Carmol 10, Keralac (urea)
Adult dosage forms and strengths
cream
- 10%
- 20%
- 30%
- 35%
- 40%
- 41%
- 45%
- 50%
lotion
- 10%
- 20%
- 25%
- 35%
- 40%
- 45%
geL
- 40%
- 45%
- 50%
suspension
- 40%
- 50%
solution
- 50%
ointment
- 10%
- 20%
- 50%
emulsion
- 40%
- 45%
- 50%
aerosol, foam
- 20%
- 30%
- 35%
- 40%
- 42%
Hyperkeratotic Skin Conditions
Indicated for hyperkeratotic conditions such as dry, rough skin; xerosis; ichthyosis; skin cracks and fissures; dermatitis; eczema; psoriasis; keratoses; and calluses
Apply topically to affected skin qDay or q8-12hr
Administration
Rub lotion/cream into skin until completely absorbed
Pediatric dosage forms and strengths
Safety and efficacy not established
Carmol 10, Keralac (urea) adverse (side) effects
Frequency not defined
Local irritation
Transient stinging
Rash
Warnings
Contraindications
Hypersensitivity
Viral skin disease
Cautions
Ischemic skin necrosis reported with high concentration or irrigation
Not for use near the eye
Pregnancy and lactation
Pregnancy category: C
Lactation: Unknown
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Carmol 10, Keralac (urea)
Mechanism of action
Elicits emollient and keratolytic effects; softens hyperkeratotic areas by disolving intracellular matrix, which subsequently loosens horny layer of the skin, or softens and debrides the nail plate
