prednisolone/sulfacetamide ophthalmic (Blephamide, Blephamide S.O.P., Cetapred, Isopto Cetapred, Vasocidin)
Dosing and uses of Blephamide, Cetapred (prednisolone-sulfacetamide-ophthalmic)
Adult dosage forms and strengths
prednisolone/sulfacetamide ophthalmic
ophthalmic ointment/suspension/solution
- 0.2/0.25%/10%
Inflammation/Infection
Ointment: 1/2 inch TID/QID & qHS Or
Suspension/Solution: 2-3 gtt q1-2hr during day & qHs
Other Indications & Uses
General antiinfective/steroid
Conjunctivitis; used for prophylaxis, & postoperative application
Sulfacetamide has fairly broad spectrum of activity but also fair amount of resistance reported; only indicated for community use (conjunctivitis, etc)
Pediatric dosage forms and strengths
Same as adult dosing
Warnings
Contraindications
Allergies to sulfa, glaucoma, Herpes, vaccinia, varicella, & other viral diseases of cornea or conjunctiva, mycobacterial infection of eye, fungal diseases of ocular structures, hypersensitivity to any ingredients
After uncomplicated removal of corneal foreign body
Cautions
Use for short term only because of steroid concerns
Watch for hypersensitivity to sulfas & steroid side effects (superinfection, glaucoma, etc)
Pregnancy and lactation
Pregnancy category: C
Lactation: not known whether topical application results in significant absorption to affect nursing infant
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
