sulfacetamide ophthalmic (Bleph 10, Sodium Sulamyd, Cetamide, Isopto Cetamide, Ocusulf 10, Ocusulf 30, Bleph 30, Sulf 10, Sulf 30, Sulfacetamide Ophth, sulfacetamide sodium)
Classes: Antibiotics, Ophthalmic
Dosing and uses of Bleph 10, Sodium Sulamyd (sulfacetamide ophthalmic)
Adult dosage forms and strengths
ophthalmic solution
- 10%
- 15%
- 30%
ointment
- 10%
Conjunctivitis
Solution: 1-3 gtt q2-3hr, taper as condition responds
Ointment 1/2 inch q3-4hr & HS; taper as condition responds
Trachoma
2 gtt q2hr concurrently with systemic therapy
Pediatric dosage forms and strengths
ophthalmic solution
- 10%
ointment
- 10%
Conjunctivitis
< 2 months
- Safety & efficacy not established
> 2 months
- Solution: 1-3 gtt q2-3hr, taper as condition responds
- Ointment 1/2 inch q3-4hr & HS; taper as condition responds
Bleph 10, Sodium Sulamyd (sulfacetamide ophthalmic) adverse (side) effects
Frequency not defined
Hypersensitivity & allergic reactions (rash, etc)
Myopia
Burning conjunctivitis
Conjunctival hyperemia
Corneal ulcers
Irritation
Stinging
Warnings
Contraindications
Sensitivity to sulfa compounds or other components
Cautions
May result in the overgrowth of nonsusceptible organisms including fungi
Severe reactions including aplastic anemia, agranylocytosis, and other blood dyscrasias reported
Dermatologic severe reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis reported
Fatal hepatic necrosis reported
Pregnancy and lactation
Pregnancy category: C
Lactation: Safety in nursing infants unknown; not recommended
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Bleph 10, Sodium Sulamyd (sulfacetamide ophthalmic)
Mechanism of action
Interfere with utilization of para-aminobenzoic or para-aminobenzoic glutamic acids by bacteria, thus inhibiting the biosynthesis of folic acid which is essential for the growth of susceptible organisms
