Dosing and uses of Besifloxacin ophthalmic (Besivance)
Adult dosage forms and strengths
ophthalmic solution
- 0.6% (5mL)
Bacterial Conjunctivitis
1 gtt in affected eye(s) three times daily (4-12 hours apart) for7 days
Pediatric dosage forms and strengths
ophthalmic solution
- 0.6% (5mL)
Bacterial Conjunctivitis
< 1 year
- Safety & efficacy not established
> 1 year
- 1 gtt in affected eye(s) three times daily (4-12 hours apart) for7 days
Besifloxacin ophthalmic (Besivance) adverse (side) effects
1-10%
Blurred vision
Conjunctival redness
Eye irritation
Eye pain
Eye pruritus
Headache
Warnings
Contraindications
None listed by the manufacturer
Cautions
May result in overgrowth of nonsusceptible organisms, including fungi
Avoid contact lenses during treatment of infections
Pregnancy and lactation
Pregnancy category: C
Lactation: Excretion in milk unknown; use caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Besifloxacin ophthalmic (Besivance)
Mechanism of action
BactericidaL
Inhibits DNA-gyrase (a topoisomerase) in susceptible organisms, which in turn inhibits cell division.
Pharmacokinetics
Half-life: 7 hr
