diphenhydramine topical (Banophen Anti-Itch, Benadryl Itch Stopping, Benadryl Extra Strength Itch Stopping, Dermamycin, Diphenhydramine-D)

Dosing and uses of Banophen Anti-Itch, Benadryl Itch Stopping (diphenhydramine topical)

• Adult
• Pediatric

 

Adult dosage forms and strengths

cream

• 2% plus zinc acetate 0.1%
• 1% plus zinc acetate 0.1%

geL

• 2%

spray

• 2% plus zinc acetate 0.1%
• 2% with menthol 1%

stick

• 2% plus zinc acetate 0.1%

 

Pruritus

Indicated for temporary relief of pain and itching associated with insect bites, minor skin irritations, and rashes due to poison ivy, poison oak, or poison sumac

Apply 1-2% topically to affected area; not to exceed 3-4 times daily

Not for use on large areas of the body

 

Pediatric dosage forms and strengths

cream

• 2% plus zinc acetate 0.1%
• 1% plus zinc acetate 0.1%

geL

• 2%

spray

• 2% plus zinc acetate 0.1%
• 2% with menthol 1%

stick

• 2% plus zinc acetate 0.1%

 

Pruritus

Indicated for temporary relief of pain and itching associated with insect bites, minor skin irritations, and rashes due to poison ivy, poison oak, or poison sumac

<2 years: Safety & efficacy not established

>2 years: Apply 1-2% topically to affected area; not to exceed 3-4 times daily

Not for use on large areas of the body

 

Banophen Anti-Itch, Benadryl Itch Stopping (diphenhydramine topical) adverse (side) effects

Frequency not defined

Skin rash

Urticaria

Photosensitivity

 

Warnings

Contraindications

Hypersensitivity

Neonates or premature infants

Breast-feeding

 

Cautions

For external use only

Not for use on large areas of the body

Do not use with any other product containing diphenhydramine

Use on chicken pox or measles only if directed by physician

 

Pregnancy and lactation

Pregnancy category: B

Lactation: Unknown if topical diphenhydramine excreted in human breastmilk; orally administered diphenhydramine is excreted into human milk and regular use is known to inhibit lactation

Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Banophen Anti-Itch, Benadryl Itch Stopping (diphenhydramine topical)

Mechanism of action

Histamine H1-receptor antagonist

 

Pharmacokinetics

Metabolism: Liver, first-pass

Excretion: Urine