diphenhydramine topical (Banophen Anti-Itch, Benadryl Itch Stopping, Benadryl Extra Strength Itch Stopping, Dermamycin, Diphenhydramine-D)
Classes: Dermatologics, Other; Antipruritics/Non-corticosteroid Topical; Antihistamines, Ethanolamine Derivatives
Dosing and uses of Banophen Anti-Itch, Benadryl Itch Stopping (diphenhydramine topical)
Adult dosage forms and strengths
cream
- 2% plus zinc acetate 0.1%
- 1% plus zinc acetate 0.1%
geL
- 2%
spray
- 2% plus zinc acetate 0.1%
- 2% with menthol 1%
stick
- 2% plus zinc acetate 0.1%
Pruritus
Indicated for temporary relief of pain and itching associated with insect bites, minor skin irritations, and rashes due to poison ivy, poison oak, or poison sumac
Apply 1-2% topically to affected area; not to exceed 3-4 times daily
Not for use on large areas of the body
Pediatric dosage forms and strengths
cream
- 2% plus zinc acetate 0.1%
- 1% plus zinc acetate 0.1%
geL
- 2%
spray
- 2% plus zinc acetate 0.1%
- 2% with menthol 1%
stick
- 2% plus zinc acetate 0.1%
Pruritus
Indicated for temporary relief of pain and itching associated with insect bites, minor skin irritations, and rashes due to poison ivy, poison oak, or poison sumac
<2 years: Safety & efficacy not established
>2 years: Apply 1-2% topically to affected area; not to exceed 3-4 times daily
Not for use on large areas of the body
Banophen Anti-Itch, Benadryl Itch Stopping (diphenhydramine topical) adverse (side) effects
Frequency not defined
Skin rash
Urticaria
Photosensitivity
Warnings
Contraindications
Hypersensitivity
Neonates or premature infants
Breast-feeding
Cautions
For external use only
Not for use on large areas of the body
Do not use with any other product containing diphenhydramine
Use on chicken pox or measles only if directed by physician
Pregnancy and lactation
Pregnancy category: B
Lactation: Unknown if topical diphenhydramine excreted in human breastmilk; orally administered diphenhydramine is excreted into human milk and regular use is known to inhibit lactation
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Banophen Anti-Itch, Benadryl Itch Stopping (diphenhydramine topical)
Mechanism of action
Histamine H1-receptor antagonist
Pharmacokinetics
Metabolism: Liver, first-pass
Excretion: Urine