tuberculin purified protein derivative (Aplisol, Mantoux, PPD, Sclavo PPD Soln, Tubersol)
Classes: Diagnostics, Antimicrobials
Dosing and uses of Aplisol, Mantoux (tuberculin purified protein derivative)
Adult dosage forms and strengths
Intradermal solution
- 5 Unit/0.1mL
Tuberculosis
Diagnosis: Mantoux test, inject 0.1 mL (5 tuberculin units) intradermally; the result is read 48 to 72 hours after administration
Positive if 10 mm induration
Use 1 TU in sensitized patients, 250 TU if no response to 5 TU
Pediatric dosage forms and strengths
Intradermal solution
- 5 Unit/0.1mL
Tuberculosis
Diagnosis: Mantoux test, inject 0.1 mL (5 tuberculin units) intradermally; the result is read 48 to 72 hours after administration
Positive if 10 mm induration
Use 1 TU in sensitized patients, 250 TU if no response to 5 TU
Geriatric dosage forms and strengths
Tuberculosis
Diagnosis: Mantoux test, inject 0.1 mL (5 tuberculin units) intradermally; the result is read 48-72 hours after administration
Positive if >10 mm induration
Use 1 TU in sensitized patients, 250 TU if no response to 5 TU
Aplisol, Mantoux (tuberculin purified protein derivative) adverse (side) effects
Suspected adverse events after administration of any vaccine may be reported to Vaccine Adverse Events Reporting System (VAERS), 1-800-822-7967
Frequency not defined
Rash
Itch
Vesiculation
Ulceration
Necrosis
Pain
Warnings
Contraindications
Previous positive tuberculin skin test responsiveness suppressed within 6 weeks of viral infection, inactive TB, immunosuppression, geriatric
Cautions
Contains soluble growth products from tubercle bacillus
Old tuberculin (OT) is culture filtrate of uniform potency
PPD is more refined and is preferred product
Multiple puncture device (Aplitest, SclavoTest-PPD, Tine Test PPD) not as sensitive
Pregnancy and lactation
Pregnancy category: C
Lactation: not known if excreted in breast milk
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Aplisol, Mantoux (tuberculin purified protein derivative)
Mechanism of action
Antigenic purified protein derivative (PPD) of Mycobacterium tuberculosis; patients become sensitized to certain antigenic components of the M. tuberculosis organism.
Pharmacokinetics
Onset of action: 5-6hr (delayed hypersensitivity reactions)
Peak effect: 48-72 hr
