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Medically reviewed by Min Clinic Staff | Updated: January 2026
Dosing and uses of Apadaz (benzhydrocodone/acetaminophen)
Moderate-to-Severe Pain
An abuse-deterrent, immediate-release formulation of prodrug benzhydrocodone plus acetaminophen that is pending FDA approval for moderate-to-severe pain
Pharmacology of Apadaz (benzhydrocodone/acetaminophen)
Mechanism of action
Benzhydrocodone: Prodrug of hydrocodone, which is an opioid analgesic agonist; blocks pain perception in the cerebral cortex; decreases synaptic chemical transmission throughout the CNS, which in turn inhibits pain sensation into higher centers
Acetaminophen: Acts on the hypothalamus to produce antipyresis; inhibits prostaglandin synthetase