Dosing and uses of Android, Methitest (methyltestosterone)
Adult dosage forms and strengths
tablet: Schedule III
- 10mg
capsule: Schedule III
- 10mg
Androgen Deficiency (Male)
Oral: 10-50 mg/day
Buccal: 5-25 mg/day
Hypogonadism, Climacteric & Impotence (Male)
Oral: 10-40 mg/day
Postpubertal Cryptorchidism (Male)
Oral: 30 mg/day
Inoperable Breast Carcinoma (Female)
Oral: 50-200 mg/day
Buccal: 25-100 mg/day
Postpartum Breast Pain & Engorgement (Female)
Oral: 80 mg/day x 3-5 days post-parturition
Buccal: 40 mg/day x 3-5 days
Other Information
Buccal absorption produces twice androgenic activity as oral tablets
Monitor: Virilization in females; priapism & excessive sexual arousal in males
Other Indications & Uses
Females: Inoperable metastatic breast cancer 1-5 years postmenopausal; post-partum breast pain & engorgement
Males: Delayed puberty
Off-label: Male climacteric impotence
Pediatric dosage forms and strengths
tablet: Schedule III
- 10mg
capsule: Schedule III
- 10mg
To Induce Pubertal Changes in Hypogonadal Males
10 mg PO qDay
Android, Methitest (methyltestosterone) adverse (side) effects
>10%
Edema
Acne
Breast soreness
Priapism
Menstrual irregularities
Virilization
Frequency not defined
Edema wiith or without congestive heart failure
Gynecomastia
Suppression of clotting factors II, V, VII & X, Erythrocytosis
Cholestatic jaundice syndrome
Neoplasm of liver
Anaphylaxis
Warnings
Contraindications
Known or suspected prostate CA, males w/ breast cancer
Pregnancy
Cautions
Cardiac dz, hepatic dz, renal dz, elderly
Hypercalcemia may occur in breast CA pts
Risk of jaundice, cholestatic hepatitis, abnl LFTs & potentially fatal hepatic peliosis - discontinue if any of these occur
Pts. easily sexually aroused
Pregnancy and lactation
Pregnancy category: X
Lactation: excreted into breast milk, avoid
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Android, Methitest (methyltestosterone)
Half-Life: 10-100 min
Peak Plasma Time: 1-2 hr
Bioavailability: absorbed from GI tract & oral mucosa
Protein Bound: 98%
Metabolism: less extensively undergoes first-pass hepatic metabolism than testosterone, suitable for PO admin
Excretion
Urine: 90%
Feces: 6%
Mechanism of action
Synthetic testosterone derivatives with anabolic & androgenic activity; promoting growth & development of male sex organs & maintaining secondary sex characteristics in androgen-deficient males
