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Medically reviewed by Min Clinic Staff | Updated: January 2026
Dosing and uses of AndexXa (andexanet alfa)
Factor Xa Reversal
Direct reversal antidote pending FDA approval for patients receiving a Factor Xa inhibitor who suffer a major bleeding episode or who may require emergency surgery
Pharmacology of AndexXa (andexanet alfa)
Mechanism of action
Acts as a Factor Xa decoy that targets and sequesters with high specificity both direct (eg, apixaban, rivaroxaban) and indirect Factor Xa inhibitors in the blood