Dosing and uses of para-aminohippurate (PAH) (aminohippurate sodium)
Adult dosage forms and strengths
injectable solution
- 20%
Renal Function Diagnostic
Used for estimation and measurement of renal function (effective renal plasma flow and tubular secretion)
Goal is to maintain plasma concentration of 2 mg/dL
Load 6-10 mg/kg, infuse at 10-24 mg/min
Pediatric dosage forms and strengths
Safety and efficacy not established
para-aminohippurate (PAH) (aminohippurate sodium) adverse (side) effects
Frequency not defined
Patients have sensations of warmth or desire to defecate or urinate during or after infusion
Hypersensitivity reactions
- Angioedema, flushing, vasomotor disturbances
- Tingling
- Urticaria
- Nausea, vomiting & cramps
- Anaphylaxis
Warnings
Contraindications
Hypersensitivity
Cautions
Low cardiac reserve
Latex sensitive individuals: Vial stopper contains dry natural latex
Administer IV solutions with caution to patients with low cardiac reserve (rapid increase in plasma volume may precipitate congestive heart failure
Pregnancy and lactation
Pregnancy category: C
Lactation: Excretion in milk unknown; use caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of para-aminohippurate (PAH) (aminohippurate sodium)
Mechanism of action
Undergoes glomerular filtration; ~90% proximal tubular secretion in a single circulation
Used to measure the functional activity of the renal tubular secretory mechanism or transport maximum (TmPAH)
Pharmacokinetics
Renal Clearance: ~90% in a single circulation at low plasma concentrations
Excretion: Urine
