5-htp (5Hydroxytryptophan, Griffonia simplicifolia, hydroxytryptophan, L5 hydroxytryptophan, L-5-HTP, oxitriptan, Tript-OH)

Suggested dosing of 5Hydroxytryptophan, Griffonia simplicifolia (5-HTP)

 

Depression

150-300 mg PO qDay

 

Primary Fibromyalgia Syndrome

100 mg PO TID for up to 1 month

 

Tetrahydrobiopterin Deficiency (Orphan)

Orphan indication sponsor

• Watson Laboratories, Inc; 311 Bonnie Circle, P.O. Box 1900; Corona, CA 91718-1900

 

Suggested uses of 5Hydroxytryptophan, Griffonia simplicifolia (5-HTP)

Anxiety, cerebellar ataxia, depression, fibromyalgia syndrome (primary), headaches (migraine/tension), myoclonus (intention/post-anoxic), Ramsey-Hunt syndrome, seizure disorder (adjunctive therapy), sleep disorders

 

Efficacy

Possibly effective for depression and fibromyalgia

 

5Hydroxytryptophan, Griffonia simplicifolia (5-HTP) adverse (side) effects

Anorexia, diarrhea, eosinophilia myalgia syndrome, eosinophilia (asymptomatic), flatulence, heartburn, nausea/vomiting, stomach pain

 

Warnings

Contraindications

None reported

 

Cautions

Down syndrome, peptic ulcers, platelet disorders, renal disease

 

Pregnancy and lactation

Pregnancy category: N/A

Lactation: N/A

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of 5Hydroxytryptophan, Griffonia simplicifolia (5-HTP)

Metabolism: N/A

Excretion: N/A

 

Mechanism of action

5-hydroxytryptophan is precursor of serotonin (5-hydroxytryptamine); boosts serotonin levels in CNs