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Singulair vs. Xyzal

Are Singulair and Xyzal the Same Thing?

Singulair (montelukast) and Xyzal (levocetirizine dihydrochloride) are used to treat allergic rhinitis.

Singulair is also used to treat asthma and for prevention of exercise-induced narrowing of the airways.

Singulair and Xyzal belong to different drug classes. Singulair is a leukotriene receptor antagonist and Xyzal is an antihistamine.

Xyzal is available over-the-counter (OTC).

Side effects of Singulair and Xyzal that are similar include diarrhea, tiredness/fatigue, stuffy nose, sore throat, and cough.

Side effects of Singulair that are different from Xyzal include skin rash, mood changes, tremors, headache, stomach pain, heartburn, upset stomach, nausea, tooth pain, fever, and hoarseness.

Side effects of Xyzal that are different from Singulair include drowsiness, weakness, sinus pain, vomiting, constipation, dry mouth, or weight gain.

Singulair may interact with phenobarbital or rifampin.

Xyzal may interact with alcohol, other medicines that can make you drowsy (cold or allergy medicine, sedatives, narcotics, sleeping pills, muscle relaxers, medicine for seizures, depression or anxiety), ritonavir, or theophylline.

What Are Possible Side Effects of Singulair?

Common side effects of Singulair include:

  • skin rash,
  • mood changes,
  • tremors,
  • headache,
  • stomach pain,
  • heartburn,
  • upset stomach,
  • nausea,
  • diarrhea,
  • tooth pain,
  • tiredness,
  • fever,
  • stuffy nose,
  • sore throat,
  • cough,
  • and hoarseness.

What Are Possible Side Effects of Xyzal?

Common side effects of Xyzal include:

  • drowsiness,
  • fatigue,
  • weakness,
  • tired feeling,
  • stuffy nose,
  • sinus pain,
  • sore throat,
  • cough,
  • vomiting,
  • diarrhea,
  • constipation,
  • dry mouth, or
  • weight gain

Tell your doctor if you have serious side effecs of Xyzal including:

  • lightheadedness,
  • nosebleeds (especially in a child),
  • pain or fullness in your ear,
  • hearing problems,
  • depression,
  • agitation,
  • aggression,
  • hallucinations,
  • numbness or tingling around your lips or mouth,
  • yellowing of your skin or eyes (jaundice),
  • painful or difficult urination,
  • dark-colored urine,
  • foul-smelling stools,
  • fever,
  • stomach pain, or
  • loss of appetite

What Is Singulair?

Singulair (montelukast) is a leukotriene receptor antagonist drug used in the treatment of asthma and allergic rhinitis. Singulair is also indicated for prevention of exercise-induced narrowing of the airways.

What Is Xyzal?

Xyzal (levocetirizine dihydrochloride) is an antihistamine indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 2 years of age and older.

What Drugs Interact With Singulair?

Singulair may interact with phenobarbital or rifampin

What Drugs Interact With Xyzal?

Xyzal may interact with alcohol, other medicines that can make you drowsy (cold or allergy medicine, sedatives, narcotics, sleeping pills, muscle relaxers, medicine for seizures, depression or anxiety). Xyzal may also interact with ritonavir or theophylline.

How Should Singulair Be Taken?

The following doses of Singulair are recommended: For adults and adolescents 15 years of age and older: one 10-mg tablet. For pediatric patients 6 to 14 years of age: one 5-mg chewable tablet. For pediatric patients 2 to 5 years of age: one 4-mg chewable tablet or one packet of 4-mg oral granules. For pediatric patients 12 to 23 months of age: one packet of 4-mg oral granules. Singulair may interact with phenobarbital or rifampin.

How Should Xyzal Be Taken?

Xyzal may interact with alcohol, other medicines that can make you drowsy (cold or allergy medicine, sedatives, narcotics, sleeping pills, muscle relaxers, medicine for seizures, depression or anxiety). Xyzal may also interact with ritonavir or theophylline.

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