Prometrium vs. Crinone

• Are Crinone and Prometrium the Same Thing?
• What Are Possible Side Effects of Prometrium?
• What Are Possible Side Effects of Crinone?
• What Is Prometrium?
• What Is Crinone?
• What Drugs Interact with Prometrium?
• What Drugs Interact with Crinone?
• How Should Prometrium Be Taken?
• How Should Crinone Be Taken?

Prometrium (progesterone) and Crinone (progesterone) are forms of the female hormone progesterone used to treat secondary amenorrhea.

Prometrium is also prescribed to prevent endometrial hyperplasia in non-hysterectomized postmenopausal women receiving conjugated estrogens tablets.

Crinone is also used to treat infertile women with progesterone deficiency.

Prometrium and Crinone are taken in different forms. Prometrium is a capsule taken orally and Crinone is a bioadhesive vaginal gel.

Common side effects of Prometrium include:

• dizziness,
• spinning sensation,
• abdominal pain (cramping),
• headache,
• breast pain or tenderness,
• musculoskeletal pain,
• joint pain,
• viral infection,
• diarrhea,
• nausea,
• bloating,
• fatigue,
• hot flashes,
• cough,
• acne,
• increased hair growth,
• changes in weight,
• vaginal itching/dryness/discharge,
• blurred vision,
• drowsiness,
• mood swings, and
• irritability.

Common side effects of Crinone include:

• bloating,
• stomach pain,
• dizziness,
• drowsiness,
• tired feeling,
• headache,
• nausea,
• vomiting,
• stomach cramps,
• diarrhea,
• constipation,
• pain in your vaginal or rectal area,
• pain during intercourse,
• loss of interest in sex,
• breast swelling or tenderness,
• joint or muscle pain,
• increased night-time urination,
• vaginal discharge,
• vaginal burning, and
• vaginal itching.

Tell your doctor if you have serious side effects of Crinone including:

• sudden headache, numbness or weakness (especially on one side of the body):
• shortness of breath, or problems with vision, speech, or balance;
• chest pain or heavy feeling, pain spreading to the arm or shoulder;
• pain or swelling in one or both legs;
• stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• swelling in your hands, ankles, or feet;
• fever, chills, body aches, flu symptoms;
• a breast lump; or
• symptoms of depression (sleep problems, weakness, mood changes).

Prometrium (progesterone) is a progestin, a female hormone, prescribed for the prevention of endometrial hyperplasia in nonhysterectomized postmenopausal women receiving conjugated estrogens tablets and also for secondary amenorrhea. Prometrium is available as a generic drug.

Crinone (progesterone) gel is a bioadhesive vaginal gel contained in single-use, one-piece polyethylene vaginal applicators. Crinone is indicated as treatment for infertile women with progesterone deficiency and women with secondary amenorrhea. Crinone is available as a generic drug.

Drug interactions include inhibitors of cytochrome P450 3A4 (for example, ketoconazole), colchicine, dabigatran etexilate (Pradaxa), silodosin (Rapaflo) and aminoglutethimide (Cytadren). Do not use Prometrium without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Talk to your doctor about using birth control while you are using Prometrium.

Crinone may interact with other drugs.

Prometrium dose depends on the condition that is being treated.

Crinone is available in strengths of 4% gel (45 mg) and 8% gel (45 mg) in single use vaginal applicators. Crinone 4% is indicated for the treatment of secondary amenorrhea is dosed every other day for 6 total doses. Crinone 8% is indicated for use in women who have failed to respond to treatment with Crinone 4% but is dosed for infertility treatment at twice daily for 10 – 12 weeks.