Pepcid vs. Prilosec

• Are Pepcid and Prilosec the Same Thing?
• What Are Possible Side Effects of Pepcid?
• What Are Possible Side Effects of Prilosec?
• What is Pepcid?
• What is Prilosec?
• What Drugs Interact with Pepcid?
• What Drugs Interact with Prilosec?
• How Should Pepcid Be Taken?
• How Should Prilosec Be Taken?

Pepcid (famotidine) and Prilosec (omeprazole) are used to treat and prevent recurrence of stomach and duodenal ulcers. Pepcid is also useful in managing heartburn, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome.

Pepcid and Prilosec belong to different drug classes. Pepcid (famotidine) is an H2-blocker and Prilosec is a proton pump inhibitor (PPI).

Pepcid and Prilosec are available over-the-counter (OTC) and in generic form.

Common side effects of Pepcid include:

• constipation,
• diarrhea,
• fatigue,
• dizziness,
• weakness,
• mood changes,
• headache,
• insomnia,
• muscle pain or cramps,
• joint pain,
• dry mouth,
• nausea, or
• vomiting.

Common side effects of Prilosec include:

• headache,
• nausea,
• vomiting,
• diarrhea,
• stomach pain,
• gas,
• constipation,
• fever, or
• cold symptoms (stuffy nose, sneezing, and sore throat).

Pepcid (famotidine) is an H2-blocker used to treat and prevent recurrence of stomach and duodenal ulcers. Pepcid is also useful in managing heartburn, gastroesophageal reflux disease and Zollinger-Ellison syndrome. Pepcid is available as a generic drug.

Prilosec (omeprazole) is a proton pump inhibitor (PPI) used for the treatment of conditions such as ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome, which are all caused by stomach acid.

Pepcid may interact with atazanavir, itraconazole, ketoconazole, or aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications and supplements you use.

Prilosec may interact with digoxin, diuretics (water pills), blood thinners, antifungal medications such as ketoconazole, antibiotics such as ampicillin, iron, or methotrexate, and HIV or AIDS medications such as atazanavir and nelfinavir.

Prilosec may also interact with bosentan, cilostazol, clopidogrel, cyclosporine, diazepam, disulfiram, St. John's wort, tacrolimus, or seizure medications.

Pepcid (famotidine) dosage depends on the condition being treated.

The recommended adult oral dose of Prilosec ranges from 20 mg to 60 mg once daily, depending on the condition being treated. For maximal efficacy, Prilosec tablets should be taken before meals, swallowed whole and should not be crushed, chewed or opened.