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Xcopri vs. Trileptal

Are Xcopri and Trileptal the Same Thing?

Xcopri (cenobamate tablets) and Trileptal (oxcarbazepine) are antiepileptic drugs (AEDs) used to treat partial-onset seizures in adult patients.

Trileptal is also used to treat partial seizures in children who are at least 2 years old.

Side effects of Xcopri and Trileptal that are similar include drowsiness, dizziness, fatigue/tired feeling, blurred or double vision, and headache.

Side effects of Trileptal that are different from Xcopri include nausea, vomiting, upset stomach, diarrhea, mental slowness, trouble concentrating, trouble sleeping, shaking, acne, skin rash, dry mouth, constipation, and problems with speech, balance, or walking.

Both Xcopri and Trileptal may interact with other antiepileptic drugs (AEDs), alcohol, and other CNS depressants.

Xcopri may also interact with CYP2B6 and CYP3A substrates, CYP2C19 substrates, oral contraceptives, and other drugs that shorten the QT interval.

Trileptal may also interact with many other drugs.

What Are Possible Side Effects of Xcopri?

Common side effects of Xcopri include:

  • drowsiness,
  • dizziness,
  • fatigue,
  • double vision, and
  • headache

What Are Possible Side Effects of Trileptal?

Common side effects of Trileptal include:

  • dizziness,
  • drowsiness,
  • tired feeling,
  • fatigue,
  • nausea,
  • vomiting,
  • upset stomach,
  • diarrhea,
  • headache,
  • mental slowness,
  • trouble concentrating,
  • trouble sleeping,
  • shaking,
  • acne,
  • skin rash,
  • blurred or double vision,
  • dry mouth,
  • constipation, and
  • problems with speech, balance, or walking.
Tell your doctor if you have serious side effects of Trileptal including:

What Is Xcopri?

Xcopri (cenobamate tablets) is an antiepileptic drug (AED) used to treat partial-onset seizures in adult patients.

What Is Trileptal?

Trileptal (oxcarbazepine) is an anticonvulsant, or antiepileptic drug, used to treat partial seizures in adults and children who are at least 2 years old. Trileptal is available in generic form.

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What Drugs Interact With Xcopri?

Xcopri may interact with other medicines such as:

  • antiepileptic drugs (AEDs),
  • CYP2B6 and CYP3A substrates,
  • CYP2C19 substrates,
  • oral contraceptives,
  • other drugs that shorten the QT interval,
  • alcohol, and
  • other CNS depressants

Tell your doctor all medications and supplements you use and all vaccines you recently received.

What Drugs Interact With Trileptal?

Trileptal may interact with other seizure medications, medicines to prevent organ transplant rejection, and heart or blood pressure medications.

 

How Should Xcopri Be Taken?

The recommended initial dosage of Xcopri is 12.5 mg once daily, adjusted to the recommended maintenance dosage of 200 mg once daily.

How Should Trileptal Be Taken?

Treatment with Trileptal starts at a dose of 600 mg/day, twice daily. If needed, the dose may be increased by a maximum of 600 mg/day at approximately weekly intervals; the recommended daily dose is 1200 mg/day.