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Xcopri vs. Neurontin

Are Xcopri and Neurontin the Same Thing?

Xcopri (cenobamate tablets) and Neurontin (gabapentin) are antiepileptic drugs (AEDs) used to treat seizures in adults.

Neurontin is also used alone or in combination with other medications to treat seizures in children who are at least 12 years old, and to treat nerve pain caused by shingles (herpes zoster).

Side effects of Xcopri and Neurontin that are similar include drowsiness, dizziness, and double vision.

Side effects of Xcopri that are different from Neurontin include fatigue and headache.

Side effects of Neurontin that are different from Xcopri include unsteadiness, memory loss, lack of coordination, difficulty speaking, viral infections, tremors, fever, unusual eye movements, jerky movements, mood or behavior changes, depression, and anxiety.

Both Xcopri and Neurontin may interact with alcohol and other CNS depressants.

Xcopri may also interact with other antiepileptic drugs (AEDs), CYP2B6 and CYP3A substrates, CYP2C19 substrates, oral contraceptives, and other drugs that shorten the QT interval.

Neurontin may also interact with hydrocodone, morphine, and naproxen.

What Are Possible Side Effects of Xcopri?

Common side effects of Xcopri include:

  • drowsiness,
  • dizziness,
  • fatigue,
  • double vision, and
  • headache

What Are Possible Side Effects of Neurontin?

Common side effects of Neurontin include:

  • dizziness,
  • drowsiness,
  • unsteadiness,
  • memory loss,
  • lack of coordination,
  • difficulty speaking,
  • viral infections,
  • tremors,
  • double vision,
  • fever,
  • unusual eye movements, and
  • jerky movements.

What Is Xcopri?

Xcopri (cenobamate tablets) is an antiepileptic drug (AED) used to treat partial-onset seizures in adult patients.

What Is Neurontin?

Neurontin is a prescription medicine used to treat:

  • Pain from damaged nerves (postherpetic pain) that follows healing of shingles (a painful rash that comes after a herpes zoster infection) in adults.
  • Partial seizures when taken together with other medicines in adults and children 3 years of age and older with seizures.

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What Drugs Interact With Xcopri?

Xcopri may interact with other medicines such as:

  • antiepileptic drugs (AEDs),
  • CYP2B6 and CYP3A substrates,
  • CYP2C19 substrates,
  • oral contraceptives,
  • other drugs that shorten the QT interval,
  • alcohol, and
  • other CNS depressants

Tell your doctor all medications and supplements you use and all vaccines you recently received.

What Drugs Interact With Neurontin?

Do Not take Neurontin if you are allergic to gabapentin or any of the other ingredients in Neurontin. See the end of this Medication Guide for a complete list of ingredients in Neurontin.

Do not drink alcohol or take other medicines that make you sleepy or dizzy while taking Neurontin without first talking with your healthcare provider. Taking Neurontin with alcohol or drugs that cause sleepiness or dizziness may make your sleepiness or dizziness worse. Do not drive, operate heavy machinery, or do other dangerous activities until you know how Neurontin affects you. Neurontin can slow your thinking and motor skills.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Taking Neurontin with certain other medicines can cause side effects or affect how well they work. Do not start or stop other medicines without talking to your healthcare provider.

Know the medicines you take. Keep a list of them and show it to your healthcare provider and pharmacist when you get a new medicine.

How Should Xcopri Be Taken?

The recommended initial dosage of Xcopri is 12.5 mg once daily, adjusted to the recommended maintenance dosage of 200 mg once daily.

How Should Neurontin Be Taken?

Take Neurontin exactly as prescribed. Your healthcare provider will tell you how much Neurontin to take.

Do not change your dose of Neurontin without talking to your healthcare provider.

If you take Neurontin tablets and break a tablet in half, the unused half of the tablet should be taken at your next scheduled dose. Half tablets not used within 28 days of breaking should be thrown away. Take Neurontin capsules with water.

Neurontin tablets can be taken with or without food. If you take an antacid containing aluminum and magnesium, such as Maalox®, Mylanta®, Gelusil®, Gaviscon®, or Di-Gel®, you should wait at least 2 hours before taking your next dose of Neurontin.

If you take too much Neurontin, call your healthcare provider or your local Poison Control Center right away at 1-800-222-1222.