Viberzi vs. Motegrity

• Are Viberzi and Motegrity the Same Thing?
• What Are Possible Side Effects of Viberzi?
• What Are Possible Side Effects of Motegrity?
• What Is Viberzi?
• What Is Motegrity?
• What Drugs Interact with Viberzi?
• What Drugs Interact with Motegrity?
• How Should Viberzi Be Taken?
• How Should Motegrity Be Taken?

Viberzi (eluxadoline) and Motegrity (prucalopride) are used in adults to treat different symptoms associated with irritable bowel syndrome (IBS).

Viberzi is used to treat irritable bowel syndrome with diarrhea (IBS-D).

Motegrity may be used off-label to treat irritable bowel syndrome with constipation (IBS-C). It is approved to treat chronic idiopathic constipation (CIC) in adults.

Viberzi and Motegrity belong to different drug classes. Viberzi is a mu-opioid receptor agonist and Motegrity is a serotonin-4 (5-HT4) receptor agonist.

Side effects of Viberzi and Motegrity that are similar include nausea, abdominal pain, vomiting, bloating, dizziness, gas, and fatigue.

Side effects of Viberzi that are different from Motegrity include constipation, upper respiratory tract infection, runny or stuffy nose, bronchitis, and rash.

Side effects of Motegrity that are different from Viberzi include headache and diarrhea.

Viberzi may interact with cyclosporine, gemfibrozil, antiretrovirals, rifampin, eltrombopag, ciprofloxacin, gemfibrozil, fluconazole, clarithromycin, paroxetine, bupropion, alosetron, anticholinergics, opioids, rosuvastatin, alfentanil, cyclosporine, dihydroergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus, or tacrolimus.

Motegrity may interact with erythromycin and ketoconazole.

Common side effects of Viberzi include:

• constipation,
• nausea,
• abdominal pain,
• upper respiratory tract infection,
• vomiting,
• runny or stuffy nose,
• bloating,
• bronchitis,
• dizziness,
• gas,
• rash, and
• fatigue.

Common side effects of Motegrity include:

• headache,
• abdominal pain,
• nausea,
• diarrhea,
• bloating,
• dizziness,
• vomiting,
• gas (flatulence), and
• fatigue

Viberzi (eluxadoline) is a mu-opioid receptor agonist used in adults to treat irritable bowel syndrome with diarrhea (IBS-D).

Motegrity (prucalopride) is a serotonin-4 (5-HT4) receptor agonist indicated for the treatment of chronic idiopathic constipation (CIC) in adults.

Viberzi may interact with other irritable bowel medications, narcotic pain medicines, or heart rhythm medications.

Viberzi may also interact with cyclosporine, gemfibrozil, antiretrovirals, rifampin, eltrombopag, ciprofloxacin, fluconazole, clarithromycin, paroxetine, bupropion, anticholinergics, opioids, rosuvastatin, dihydroergotamine, ergotamine, pimozide, sirolimus, or tacrolimus.

Motegrity may interact with erythromycin or ketoconazole. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Motegrity; it is unknown how it would affect a fetus. Motegrity passes into breast milk. Consult your doctor before breastfeeding.

The recommended dosage of Viberzi in adults is 100 mg twice daily, taken with food.

The recommended dose of Motegrity is 2 mg once daily.