Vasotec vs. Entresto

• Are Vasotec and Entresto the Same Thing?
• What Are Possible Side Effects of Vasotec?
• What Are Possible Side Effects of Entresto?
• What Is Vasotec?
• What Is Entresto?
• What Drugs Interact with Vasotec?
• What Drugs Interact with Entresto?
• How Should Vasotec Be Taken?
• How Should Entresto Be Taken?

Vasotec (enalapril maleate) and Entresto (sacubitril and valsartan) are used to treat heart failure.

Vasotec is also used to treat high blood pressure (hypertension), kidney problems caused by diabetes, and to improve survival after a heart attack.

Vasotec and Entresto belong to different drug classes. Vasotec is an ACE (angiotensin converting enzyme) inhibitor and Entresto is a combination of a neprilysin inhibitor and an angiotensin II receptor blocker (ARB).

Side effects of Vasotec and Entresto that are similar include dizziness.

Side effects of Vasotec that are different from Entresto include lightheadedness or weakness as your body adjusts to the medication.

Side effects of Entresto that are different from Vasotec include low blood pressure (hypotension), high blood potassium (hyperkalemia), cough, dizziness, and kidney (renal) failure.

Both Vasotec and Entresto may interact with lithium, aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), or diuretics (water pills).

Vasotec may also interact with alcohol, gold injections to treat arthritis, potassium supplements, and salt substitutes that contain potassium.

Entresto may also interact with angiotensin-converting-enzyme (ACE) inhibitors and other angiotensin receptor blockers (ARBs).

Common side effects of Vasotec include:

• dizziness,
• lightheadedness, or
• weakness as your body adjusts to the medication.

Tell your doctor if you have unlikely but serious side effects of Vasotec including:

• dry cough,
• loss of taste sensation,
• loss of appetite,
• drowsiness,
• headache,
• sleep problems (insomnia),
• dry mouth,
• nausea,
• vomiting,
• diarrhea, or
• skin itching or rash.
• fainting,
• symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat, weak pulse, tingly feeling),
• signs of infection (such as fever, chills, persistent sore throat, body aches, flu symptoms),
• changes in the amount of urine,
• swelling, rapid weight gain,
• confusion, increased thirst, loss of appetite, vomiting, pounding heartbeats or fluttering in your chest,
• pale skin, easy bruising or bleeding,
• fast or uneven heartbeats,
• chest pain, or
• yellowing of the skin or eyes (jaundice).

Common side effects of Entresto include:

• low blood pressure (hypotension),
• high blood potassium (hyperkalemia),
• cough,
• dizziness, and
• kidney (renal) failure

Vasotec (enalapril maleate) is an ACE (angiotensin converting enzyme) inhibitor used to treat high blood pressure (hypertension), congestive heart failure, kidney problems caused by diabetes, and to improve survival after a heart attack.

Entresto (sacubitril and valsartan) is a combination of a neprilysin inhibitor and an angiotensin II receptor blocker indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.

Vasotec may interact with gold injections to treat arthritis, lithium, potassium supplements, salt substitutes that contain potassium, aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs), or diuretics (water pills). Tell your doctor all medications and supplements you use. Vasotec is not recommended for use during pregnancy. It may harm a fetus. This medication passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breastfeeding.

Entresto may interact with angiotensin-converting-enzyme (ACE) inhibitors, other angiotensin receptor blockers (ARBs), potassium-sparing diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), or lithium. Tell your doctor all medications and supplements you use. Entresto is not recommended for use during pregnancy. It may harm a fetus. Entresto is not recommended for use while breastfeeding.

Dose of Vasotec varies depending on the condition being treated.

Entresto (ziprasidone HCl) is available as capsules and Entresto (ziprasidone mesylate) is available as an injection for intramuscular use.

Entresto Capsules should be administered at an initial daily dose of 20 mg twice daily with food. For intramuscular dosing, the recommended dose of Entresto is 10 mg to 20 mg administered as required up to a maximum dose of 40 mg per day.