Talicia vs. Flagyl

• Are Flagyl and Talicia the Same Thing?
• What Are Possible Side Effects of Talicia?
• What Are Possible Side Effects of Flagyl?
• What is Talicia?
• What is Flagyl?
• What Drugs Interact with Talicia?
• What Drugs Interact with Flagyl?
• How Should Talicia Be Taken?
• How Should Flagyl Be Taken?

Talicia (omeprazole magnesium, amoxicillin and rifabutin) and Flagyl, Flagyl ER, and Flagyl Injection (metronidazole) are used to treat Helicobacter pylori infection in adults.

Flagyl may be given in combination with other medications to treat Helicobacter pylori infection. Flagyl is also used to treat bacterial vaginosis, trichomonas, amebiasis, and anaerobic bacterial infections.

Talicia and Flagyl belong to different drug classes. Talicia is a combination of a proton pump inhibitor, a penicillin-class antibiotic, and a rifamycin antibacterial and Flagyl is an antibiotic and antiprotozoal medication.

Side effects of Talicia and Flagyl that are similar include diarrhea, headache, nausea, vomiting, abdominal pain/cramps, and abnormally colored urine.

Side effects of Talicia that are different from Flagyl include rash, heartburn/indigestion, mouth and throat pain, and vaginal yeast infection.

Side effects of Flagyl that are different from Talicia include stomach upset, constipation, weight loss, dizziness, dry mouth, and a metallic taste in the mouth or changes in taste.

Both Talicia and Flagyl may interact with blood thinners.

Talicia may also interact with voriconazole, St. John's wort, rifampin, ritonavir, fluconazole, posaconazole, itraconazole, clopidogrel, citalopram, cilostazol, phenytoin, diazepam, antiretrovirals, protease inhibitors, probenecid, allopurinol, methotrexate, digoxin, cyclosporine, disulfiram, and hormonal contraceptives.

Flagyl may also interact with alcohol, propylene glycol, busulfan, and lithium.

Common side effects of Talicia include:

• diarrhea,
• headache,
• nausea,
• abdominal pain,
• abnormally colored urine,
• rash,
• heartburn/indigestion,
• mouth and throat pain,
• vomiting, and
• vaginal yeast infection

Common side effects of Flagyl include:

• nausea,
• abdominal cramps,
• stomach upset,
• vomiting,
• diarrhea,
• constipation,
• headache,
• weight loss (anorexia),
• dizziness,
• dry mouth,
• dark-colored urine, or
• a metallic taste in the mouth or changes in taste.

Uncomfortable side effects that may become serious are:

• fevers,
• pain with urination,
• mouth sores,
• tingling or pricking sensations that may become permanent,
• brain disease, and
• seizures.

Serious but unlikely side effects of Flagyl include:

• unsteadiness,
• seizures,
• mood changes,
• numbness or tingling of the hands or feet, and
• painful urination.

Talicia (omeprazole magnesium, amoxicillin and rifabutin) is a three-drug combination of:

• a proton pump inhibitor,
• a penicillin-class antibacterial, and
• a rifamycin antibacterial indicated for the treatment of Helicobacter pylori infection in adults.

Flagyl, Flagyl ER, and Flagyl Injection (metronidazole) are antimicrobial drugs used to treat bacterial vaginosis, trichomonas, amebiasis, and anaerobic bacterial infections.

Talicia may interact with other medicines such as:

• voriconazole,
• St. John's wort,
• rifampin,
• ritonavir,
• fluconazole,
• posaconazole,
• itraconazole,
• clopidogrel,
• citalopram,
• cilostazol,
• phenytoin,
• diazepam,
• antiretrovirals,
• protease inhibitors,
• probenecid,
• allopurinol,
• oral anticoagulants,
• methotrexate,
• digoxin,
• cyclosporine,
• disulfiram, and
• hormonal contraceptives

Flagyl may interact with blood thinners or seizure medications.

Flagyl may also interact with cimetidine, lithium, or disulfiram.

Flagyl may also interact with colchicine, itraconazole, omeprazole, ranitidine, bismuth citrate, sildenafil, tadalafil, vardenafil, tolterodine, steroids, or insulin or oral diabetes medications.

The dosage of Talicia is four (4) capsules every 8 hours with food for 14 days.

Flagyl is supplied in 250 and 500 mg strength tablets, Flagyl ER is available in 750 mg strength tablets, and Flagyl Injection in 500 mg strength in a buffered 100 ml vial. Dosage is quite variable and dependent upon the severity of disease and other considerations made by the treating physician. Most of the serious side effects may occur with any of these three preparations of Flagyl. Flagyl may cause liver enzyme levels to increase; lithium and creatinine levels should be checked to avoid lithium toxicity or renal compromise. Alcohol may increase the side effects of Flagyl. Patients on disulfiram should not take Flagyl until they have had a two week interval without taking disulfiram, especially alcoholic patients, to avoid psychotic reactions. Treatment in pregnant women (during first 3 months is not advised) or women who are breastfeeding should only be done if the benefits outweigh the potential problems. Flagyl passes into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding. Except for use in amebiasis, studies in pediatric patients are not available; Flagyl ER has no pediatric studies.