Semlgee vs. Tresiba

Semglee (insulin glargine injection) and Tresiba (insulin degludec injection) are long-acting human insulin analogs indicated to improve glycemic control in adults with diabetes mellitus.

Semglee is also indicated to improve glycemic control in pediatric patients with type 1 diabetes mellitus.

Side effects of Semglee and Tresiba that are similar include low blood sugar (hypoglycemia), allergic reactions, injection site reactions, changes in body fat distribution (lipodystrophy), itching, rash, fluid retention (edema), and weight gain.

Side effects of Tresiba that are different from Semglee include runny or stuffy nose, upper respiratory tract infection, headache, sinusitis, upset stomach or stomach pain, and diarrhea.

Both Semglee and Tresiba may interact with antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors (MAOIs), pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), sulfonamide antibiotics, atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), thyroid hormones, alcohol, beta-blockers, clonidine, lithium salts, guanethidine, and reserpine.

Tresiba may also interact with propoxyphene, other insulin products, GLP-1 receptor agonists, DDP-4 inhibitors, SGLT-2 inhibitors, and pentamidine.

Common side effects of Semlgee include:

• low blood sugar (hypoglycemia),
• allergic reactions,
• injection site reactions,
• changes in body fat distribution (lipodystrophy),
• itching,
• rash,
• fluid retention (edema),
• and weight gain

Common side effects of Tresiba include:

• low blood sugar (hypoglycemia),
• allergic reactions,
• injection site reactions,
• body fat redistribution (lipodystrophy),
• itching,
• rash,
• swelling,
• weight gain,
• runny or stuffy nose,
• upper respiratory tract infection,
• headache,
• sinusitis,
• upset stomach or stomach pain, and
• diarrhea.

Semglee (insulin glargine injection) is a long-acting human insulin analog indicated to improve glycemic control in adults and pediatric patients with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus.

Tresiba (insulin degludec injection) is a long-acting human insulin analog indicated to improve glycemic control in adults with diabetes mellitus.

Semglee may interact with other medicines such as:

• antidiabetic agents,
• ACE inhibitors,
• angiotensin II receptor blocking agents,
• disopyramide,
• fibrates,
• fluoxetine,
• monoamine oxidase inhibitors (MAOIs),
• pentoxifylline,
• pramlintide,
• salicylates,
• somatostatin analog (e.g., octreotide),
• sulfonamide antibiotics,
• atypical antipsychotics,
• corticosteroids,
• danazol,
• diuretics,
• estrogens,
• glucagon,
• isoniazid,
• niacin,
• oral contraceptives,
• phenothiazines,
• progestogens (e.g., in oral contraceptives),
• protease inhibitors,
• somatropin,
• sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline),
• thyroid hormones
• ,
• alcohol,
• beta-blockers,
• clonidine,
• lithium salts,
• guanethidine, and
• reserpine

Tell your doctor all medications and supplements you use.

Tresiba may interact with other insulin products, beta-blockers, clonidine, guanethidine, reserpine, other antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs, sulfonamide antibiotics, GLP-1 receptor agonists, DDP-4 inhibitors, SGLT-2 inhibitors, atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens, protease inhibitors, somatropin, sympathomimetic agents, thyroid hormones, alcohol, lithium salts, or pentamidine. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant while taking Tresiba. During pregnancy, Tresiba should only be taken if prescribed. It is unknown if Tresiba passes into breast milk. Women with diabetes who are nursing may require adjustments in insulin dose, meal plan, or both. Consult your doctor before breastfeeding.

The dose of Semglee is individualized based on the patient's metabolic needs, blood glucose monitoring, glycemic control, type of diabetes, and prior insulin use.

The dose of Tresiba is individualized based on type of diabetes, metabolic needs, blood glucose monitoring results, and glycemic control goal.