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Nayzilam vs. Onfi

Are Nayzilam and Onfi the Same Thing?

Nayzilam (midazolam) Nasal Spray and Onfi (clobazam) are benzodiazepines used to treat different types of seizures.

Nayzilam is used for acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern in patients with epilepsy 12 years of age and older.

Onfi is used as an add-on treatment for seizures associated with Lennox-Gastaut syndrome (LGS) in patients 2 years of age or older.

Side effects of Nayzilam and Onfi that are similar include drowsiness.

Side effects of Nayzilam that are different from Onfi include headache, nasal discomfort, throat irritation, and runny nose.

Side effects of Onfi that are different from Nayzilam include dizziness, sedation, slow thinking, impaired motor skills, sleepiness, weakness, tiredness, fever, drooling, constipation, dry cough, urinary tract infection (UTI), sleep problems (insomnia), aggression, fatigue, upper respiratory tract infection, irritability, vomiting, problems swallowing, slurred speech, problems with coordination or balance, appetite changes, bronchitis, and pneumonia.

Both Nayzilam and Onfi may interact with other drugs that can make you sleepy (other benzodiazepines and sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, opioids, alcohol).

Nayzilam may also interact with ketoconazole, itraconazole, and clarithromycin.

Onfi may also interact with cimetidine, fluvastatin, indomethacin, probenecid, ropinirole, tamsulosin, terbinafine, ticlopidine, tolterodine, felbamate, oxcarbazepine, lansoprazole, omeprazole, ADHD medications, antidepressants, antifungals, anti-malaria medications, cancer medicines, cough medicines, heart or blood pressure medications, and HIV/AIDS medications.

Withdrawal symptoms may occur if you suddenly stop taking Nayzilam or Onfi.

What Are Possible Side Effects of Nayzilam?

Common side effects of Nayzilam include:

  • drowsiness,
  • headache,
  • nasal discomfort,
  • throat irritation, and
  • runny nose

What Are Possible Side Effects of Onfi?

Common side effects of Onfi include:

  • drowsiness,
  • dizziness,
  • sedation,
  • slow thinking,
  • impaired motor skills,
  • sleepiness,
  • sedation,
  • weakness,
  • tiredness,
  • fever,
  • drooling,
  • constipation,
  • dry cough,
  • urinary tract infection,
  • sleep problems (insomnia),
  • aggression,
  • fatigue,
  • upper respiratory tract infection,
  • irritability,
  • vomiting,
  • problems swallowing,
  • slurred speech,
  • problems with coordination or balance,
  • appetite changes,
  • bronchitis, and
  • pneumonia.

Serious side effects of Onfi include suicidal behavior. Tell your doctor if this occurs.

What Is Nayzilam?

Nayzilam (midazolam) is a benzodiazepine indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern in patients with epilepsy 12 years of age and older.

What Is Onfi?

Onfi (clobazam) is a benzodiazapine for use as an add-on treatment for seizures associated with Lennox-Gastaut syndrome (LGS) in patients 2 years of age or older.

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What Drugs Interact With Nayzilam?

Nayzilam may interact with other drugs that can make you sleepy (other benzodiazepines and sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, opioids, alcohol), ketoconazole, itraconazole, and clarithromycin. Tell your doctor all medications and supplements you use.

What Drugs Interact With Onfi?

Onfi may interact with other medicines that make you sleepy (such as cold or allergy medicines, other sedatives, narcotics, sleeping pills, muscle relaxers, and medicines for seizures, depression, or anxiety), cimetidine, fluvastatin, indomethacin, probenecid, ropinirole, tamsulosin, terbinafine, ticlopidine, tolterodine, felbamate, oxcarbazepine, lansoprazole, omeprazole, ADHD medications, antidepressants, antifungals, anti-malaria medications, cancer medicines, cough medicines, heart or blood pressure medications, HIV/AIDS medications, or medicines to treat psychiatric disorders. Tell your doctor all medications and supplements you use. Onfi may compromise the effectiveness of some birth control medications. Women should tell their healthcare providers if they are pregnant, planning to become pregnant, or are using birth control medications. Onfi may pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding. Onfi may have harmful effects on unborn babies to include breathing and feeding problems, dangerously low body temperatures, and withdrawal symptoms. It is approved for children 2 years and older.

 

How Should Nayzilam Be Taken?

The initial dose of Nayzilam is one spray (5 mg dose) administered into one nostril. A second dose of one additional spray (5 mg dose) Nayzilam may be administered into the opposite nostril after 10 minutes if the patient has not responded to the initial dose.

How Should Onfi Be Taken?

Onfi is available in 5 mg, 10 mg, and 20 mg strengths and can be administered whole, or crushed and mixed in applesauce. Dosing depends on body weight. It is important that people taking Onfi not drive, operate heavy machinery, or engage in other dangerous activities. Onfi can cause abuse and dependence and should not be used with alcohol. Abrupt discontinuation of Onfi should be avoided. The risk of withdrawal symptoms (for example, seizures, tremors, anxiety) is greater with higher doses.