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Nayzilam vs. Fycompa

Are Nayzilam and Fycompa the Same Thing?

Nayzilam (midazolam) Nasal Spray and Fycompa (perampanel) are used to treat different types of seizures in patients with epilepsy ages 12 years and older.

Nayzilam is used for acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern.

Fycompa is used treat drug-resistant partial-onset seizures.

Nayzilam and Fycompa belong to different drug classes. Nayzilam is a benzodiazepine and Fycompa is a non-competitive AMPA receptor antagonist.

Side effects of Nayzilam and Fycompa that are similar include drowsiness and headache.

Side effects of Nayzilam that are different from Fycompa include nasal discomfort, throat irritation, and runny nose.

Side effects of Fycompa that are different from Nayzilam include dizziness, sleepiness, tiredness, fatigue, irritability, nausea, weight gain, joint pain, back pain, and problems maintaining balance.

Both Nayzilam and Fycompa may interact with other drugs that can make you sleepy (other benzodiazepines and sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, opioids, alcohol).

Nayzilam may also interact with ketoconazole, itraconazole, and clarithromycin.

Fycompa may also interact with bosentan, nafcillin, pentobarbital, St. John's wort, rifabutin, rifapentine, rifampin, and HIV medications.

Withdrawal symptoms may occur if you suddenly stop taking Nayzilam. If a patient withdraws from Fycompa, there may be an increase in the frequency of seizures.

What Are Possible Side Effects of Nayzilam?

Common side effects of Nayzilam include:

  • drowsiness,
  • headache,
  • nasal discomfort,
  • throat irritation, and
  • runny nose

What Are Possible Side Effects of Fycompa?

Common side effects of Fycompa include:

  • dizziness,
  • sleepiness,
  • drowsiness,
  • tiredness,
  • fatigue,
  • headache,
  • irritability,
  • nausea,
  • weight gain,
  • joint pain,
  • back pain, and
  • problems maintaining balance.

Contact your doctor if you experience serious psychiatric and behavioral side effects of Fycompa including:

  • changes in mood, behavior, or personality,
  • aggression,
  • hostility,
  • irritability,
  • anger,
  • anxiety,
  • unusual thoughts,
  • paranoid behavior,
  • panic attacks,
  • thoughts about hurting someone else, and
  • suicidal or homicidal ideation and threats.

Tell your doctor if you have serious side effects of Fycompa including trouble sleeping, talking more than usual, trouble walking, loss of balance or coordination, an accidental fall, severe dizziness, spinning sensation (vertigo), or feeling like you might pass out.

What Is Nayzilam?

Nayzilam (midazolam) is a benzodiazepine indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern in patients with epilepsy 12 years of age and older.

What Is Fycompa?

Fycompa (perampanel) is a non-competitive AMPA receptor antagonist, which belongs to a new class of drugs to treat drug-resistant partial-onset seizures in patients with epilepsy ages 12 years and older.

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What Drugs Interact With Nayzilam?

Nayzilam may interact with other drugs that can make you sleepy (other benzodiazepines and sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, opioids, alcohol), ketoconazole, itraconazole, and clarithromycin. Tell your doctor all medications and supplements you use.

What Drugs Interact With Fycompa?

Fycompa may interact with other drugs that make you sleepy or slow your breathing (sleeping pills, narcotic pain medicines, muscle relaxers, or medicines for anxiety, depression, or seizures), bosentan, nafcillin, pentobarbital, St. John's wort, rifabutin, rifapentine, rifampin, and HIV medications. Tell your doctor all medications and supplements you use.

 

How Should Nayzilam Be Taken?

The initial dose of Nayzilam is one spray (5 mg dose) administered into one nostril. A second dose of one additional spray (5 mg dose) Nayzilam may be administered into the opposite nostril after 10 minutes if the patient has not responded to the initial dose.

How Should Fycompa Be Taken?

Starting dose of Fycompa is 2 mg taken once daily at bedtime. Patients taking anti-eleptic drugs (AEDs) should start on 4 mg of Fycompa. Dosage may be increased based on how well patients tolerate Fycompa. The maximum recommended dose is 12 mg taken once daily. Fycompa is not recommended for patients with decreased liver or kidney function, or patients on dialysis.