Mayzent vs. Gilenya

• Are Mayzent and Gilenya the Same Thing?
• What Are Possible Side Effects of Mayzent?
• What Are Possible Side Effects of Gilenya?
• What Is Mayzent?
• What Is Gilenya?
• What Drugs Interact with Mayzent?
• What Drugs Interact with Gilenya?
• How Should Mayzent Be Taken?
• How Should Gilenya Be Taken?

Mayzent (siponimod) and Gilenya (fingolimod) are sphingosine 1-phosphate receptor modulators used to treat relapsing forms of multiple sclerosis (MS).

Side effects of Mayzent and Gilenya that are similar include headache, increased liver transaminase, and diarrhea.

Side effects of Mayzent that are different from Gilenya include high blood pressure (hypertension), falls, pain and swelling in extremities, nausea, dizziness, and slow heart rate.

Side effects of Gilenya that are different from Mayzent include tired feeling, influenza, stuffy nose, sinus pain, diarrhea, back pain, and cough.

Both Mayzent and Gilenya may interact with “live” vaccines, cancer medications, immune-modulating drugs, immunosuppressive therapies, calcium channel blockers, and beta-blockers.

Mayzent may interact with anti-arrhythmics, QT prolonging drugs, other drugs that may decrease heart rate, fluconazole, rifampin, carbamazepine, modafinil, or efavirenz.

Gilenya may interact with citalopram, chlorpromazine, digoxin, erythromycin, haloperidol, ketoconazole, heart problems, or high blood pressure, and methadone.

Common side effects of Mayzent include:

• headache,
• high blood pressure (hypertension),
• increased transaminase,
• falls,
• swelling of extremities,
• nausea,
• dizziness,
• diarrhea,
• slow heart rate, and
• pain in extremities

Common side effects of Gilenya include:

• headache,
• tired feeling,
• influenza,
• stuffy nose,
• sinus pain,
• diarrhea,
• back pain,
• liver transaminase elevations, and
• cough.

Gilenya can affect your immune system's ability to fight an infection while you are taking the medication and for 2 months after your last dose. Tell your doctor right away if you develop signs of an infection such as:

• persistent cough or sore throat,
• difficulty breathing,
• fever,
• chills, or
• cold/flu symptoms.

Mayzent (siponimod) is a sphingosine 1-phosphate receptor modulator indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

Gilenya (fingolimod) is a sphingosine 1-phosphate receptor modulator used to treat patients with relapsing forms of multiple sclerosis (MS) to reduce the frequency of exacerbations and to delay physical disability.

Mayzent may interact with:

• "live" vaccines,
• cancer medications,
• immune-modulating drugs,
• immunosuppressive therapies,
• anti-arrhythmics,
• QT prolonging drugs,
• calcium channel blockers,
• other drugs that may decrease heart rate,
• beta-blockers,
• fluconazole,
• rifampin,
• carbamazepine,
• modafinil, or
• efavirenz.

Gilenya may interact with:

• beta-blockers,
• calcium channel blockers,
• citalopram,
• chlorpromazine,
• digoxin,
• erythromycin,
• haloperidol,
• ketoconazole,
• medications to control the immune system,
• medications for cancer, heart problems, or high blood pressure, and
• methadone

Tell your doctor all medications and supplements you use. Gilenya may cause fetal harm. It takes approximately 2 months for Gilenya to be eliminated from the body. Women should avoid pregnancy during treatment with Gilenya and for 2 months after treatment. It is not known if Gilenya passes into breast milk. Women and their doctors should decide whether to take Gilenya or breastfeed. Women should not do both.

Initiate Mayzent with a 5-day titration. The recommended maintenance dosage of Mayzent is 2 mg.

The recommended dose for Gilenya is 0.5 mg orally once daily, with or without food.