Lomotil vs. Viberzi

• Are Lomotil and Viberzi the Same Thing?
• What Are Possible Side Effects of Lomotil?
• What Are Possible Side Effects of Viberzi?
• What Is Lomotil?
• What Is Viberzi?
• What Drugs Interact with Lomotil?
• What Drugs Interact with Viberzi?
• How Should Lomotil Be Taken?
• How Should Viberzi Be Taken?

Lomotil (diphenoxylate and atropine) and Viberzi (eluxadoline) are used treat diarrhea.

Viberzi is specifically used in adults to treat diarrhea associated with irritable bowel syndrome with diarrhea (IBS-D).

Viberzi and Lomotil belong to different drug classes. Viberzi is a mu-opioid receptor agonist and Lomotil is a combination antidiarrheal medication, and an anticholinergic.

Common side effects of Lomotil include:

• drowsiness,
• dizziness,
• headache,
• tiredness,
• restlessness,
• blurred vision,
• dry mouth,
• nausea,
• vomiting,
• upset stomach,
• loss of appetite,
• skin rash, or
• itching.

Tell your doctor if you experience unlikely but serious side effects of Lomotil including:

• stomach or abdominal pain or swelling,
• severe nausea or vomiting,
• mental/mood changes (e.g., confusion, depression), or
• numbness and tingling of arms or legs.

Common side effects of Viberzi include:

• constipation,
• nausea,
• abdominal pain,
• upper respiratory tract infection,
• vomiting,
• runny or stuffy nose,
• bloating,
• bronchitis,
• dizziness,
• gas,
• rash, and
• fatigue.

Lomotil (diphenoxylate and atropine) is a combination antidiarrheal medication, and an anticholinergic used to treat diarrhea.

Viberzi (eluxadoline) is a mu-opioid receptor agonist used in adults to treat irritable bowel syndrome with diarrhea (IBS-D).

Lomotil may interact with barbiturates or MAO inhibitors. Lomotil may interact with other drugs. Tell your doctor all prescription and over-the-counter medications and supplements you use.

Viberzi may interact with other irritable bowel medications, narcotic pain medicines, or heart rhythm medications.

Viberzi may also interact with cyclosporine, gemfibrozil, antiretrovirals, rifampin, eltrombopag, ciprofloxacin, fluconazole, clarithromycin, paroxetine, bupropion, anticholinergics, opioids, rosuvastatin, dihydroergotamine, ergotamine, pimozide, sirolimus, or tacrolimus.

The recommended initial adult dosage is two Lomotil tablets four times daily or 10 ml (two regular tsp) of Lomotil liquid four times daily (20 mg per day). The pediatric dose is determined by the child's weight.

The recommended dosage of Viberzi in adults is 100 mg twice daily, taken with food.