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Linzess vs. Motegrity

Are Linzess and Motegrity the Same Thing?

Linzess (linaclotide) and Motegrity (prucalopride) are used in adults to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C).

Motegrity may be used off-label to treat irritable bowel syndrome with constipation (IBS-C).

Linzess and Motegrity belong to different drug classes. Linzess is a guanylate cyclase-C agonist and Motegrity is a serotonin-4 (5-HT4) receptor agonist.

Side effects of Linzess and Motegrity that are similar include diarrhea, stomach/abdominal pain or discomfort, gas, bloating, vomiting, and headache.

Side effects of Linzess that are different from Motegrity include heartburn, and cold symptoms such as stuffy nose, sneezing, or sinus pain.

Side effects of Motegrity that are different from Linzess include nausea, dizziness, and fatigue.

Linzess may interact with other drugs.

Motegrity may interact with erythromycin and ketoconazole.

What Are Possible Side Effects of Linzess?

Common side effects of Linzess include:

  • diarrhea,
  • stomach/abdominal pain or discomfort,
  • gas,
  • bloating,
  • heartburn,
  • vomiting,
  • headache, or
  • cold symptoms such as stuffy nose, sneezing, or sinus pain.

What Are Possible Side Effects of Motegrity?

Common side effects of Motegrity include:

  • headache,
  • abdominal pain,
  • nausea,
  • diarrhea,
  • bloating,
  • dizziness,
  • vomiting,
  • gas (flatulence), and
  • fatigue

What Is Linzess?

Linzess (linaclotide) is a guanylate cyclase-C agonist used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults.

What Is Motegrity?

Motegrity (prucalopride) is a serotonin-4 (5-HT4) receptor agonist indicated for the treatment of chronic idiopathic constipation (CIC) in adults.

 

What Drugs Interact With Linzess?

Linzess may interact with other drugs.

What Drugs Interact With Motegrity?

Motegrity may interact with erythromycin or ketoconazole. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Motegrity; it is unknown how it would affect a fetus. Motegrity passes into breast milk. Consult your doctor before breastfeeding.

 

How Should Linzess Be Taken?

The recommended dose of Linzess for those with irritable bowel syndrome (IBS) is 290 mcg taken once a day on an empty stomach, at least 30 minutes before the first meal of the day. The same applies for those with chronic idiopathic constipation only the dosage is 145 mcg. Pediatric patients under the age of 17 should not take Linzess.

How Should Motegrity Be Taken?

The recommended dose of Motegrity is 2 mg once daily.