Ibsrela vs. Xifaxan
Are Ibsrela and Xifaxan the Same Thing?
Ibsrela (tenapanor) and Xifaxan (rifaximin) are used to treat different symptoms of irritable bowel syndrome (IBS).
Ibsrela is used to treat irritable bowel syndrome with constipation (IBS-C) in adults.
Xifaxan is used to treat irritable bowel syndrome with diarrhea (IBS-D). Xifaxan is also used to treat patients 12 years of age and older with travelers' diarrhea caused by noninvasive strains of Escherichia coli (E. coli), and to lower the risk of worsened brain function, or hepatic encephalopathy, in adults with liver failure.
Ibsrela and Xifaxan belong to different drug classes. Ibsrela is a sodium/hydrogen exchanger 3 (NHE3) inhibitor and Xifaxan is an antibiotic.
Side effects of Ibsrela and Xifaxan that are similar include abdominal distension/bloating, gas (flatulence), and dizziness.
Side effects of Ibsrela that are different from Xifaxan include diarrhea.
Side effects of Xifaxan that are different from Ibsrela include nausea, vomiting, constipation, stomach pain, feeling like you need to urgently empty your bowel, feeling your bowel is not completely empty, headache, tired feeling, and swelling in your hands, feet, or torso.
Ibsrela may interact with other drugs.
Xifaxan may interact with cyclosporine, ketoconazole, warfarin, other antibiotics, antiviral medicines, and heart or blood pressure medicines.
What Are Possible Side Effects of Ibsrela?
Common side effects of Ibsrela include:
- diarrhea,
- abdominal distension,
- gas (flatulence), and
- dizziness.
What Are Possible Side Effects of Xifaxan?
Common side effects of Xifaxan include:
- nausea,
- vomiting,
- constipation,
- bloating,
- gas,
- stomach pain,
- feeling like you need to urgently empty your bowel,
- feeling your bowel is not completely empty,
- headache,
- dizziness,
- tired feeling, or
- swelling in your hands, feet, or torso.
Tell your doctor if you develop serious side effects of Xifaxan including:
What Is Ibsrela?
Ibsrela (tenapanor) is a sodium/hydrogen exchanger 3 (NHE3) inhibitor indicated for treatment of irritable bowel syndrome with constipation (IBS-C) in adults.
What Is Xifaxan?
Xifaxan (rifaximin) is an antibiotic indicated for the treatment of patients 12 years of age and older with travelers' diarrhea caused by noninvasive strains of Escherichia coli (E. coli), and to lower the risk of worsened brain function, or hepatic encephalopathy, in adults with liver failure.
What Drugs Interact With Ibsrela?
Ibsrela may interact with other drugs. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Ibsrela; maternal use is not expected to result in fetal exposure to the drug. It is unknown if Ibsrela passes into breast milk. Consult your doctor before breastfeeding.
What Drugs Interact With Xifaxan?
Xifaxan may interact with other drugs. Tell your doctor all medications and supplements you use.
How Should Ibsrela Be Taken?
The recommended dosage of Ibsrela in adults is 50 mg, orally twice daily.
How Should Xifaxan Be Taken?
Xifaxan (rifaximin) tablets for oral administration are film-coated and contain 200 or 550 mg of rifaximin. Usual dosage is 200 mg three times a day for three days for diarrhea and 550mg twice a day for 3 days for hepatic encephalopathy.
All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).
Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.
Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.
The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.
As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.
Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.
If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.
You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.