Emgality vs. Trokendi XR

• Are Emgality and Trokendi XR the Same Thing?
• What Are Possible Side Effects of Emgality?
• What Are Possible Side Effects of Trokendi XR?
• What Is Emgality?
• What Is Trokendi XR?
• What Drugs Interact with Emgality?
• What Drugs Interact with Trokendi XR?
• How Should Emgality Be Taken?
• How Should Trokendi XR Be Taken?

Emgality (galcanezumab-gnlm) and Trokendi XR (topiramate) are used to prevent migraine in adults.

Trokendi XR is also used as initial monotherapy in patients 10 years of age and older with partial onset or primary generalized tonic-clonic seizures and adjunctive therapy in patients 6 years of age and older with partial onset or primary generalized tonic-clonic seizures.

Emgality is a calcitonin-gene related peptide antagonist and Trokendi XR is a sulfamate-substituted monosaccharide.

Side effects of Emgality that are different from Trokendi XR include injection site reactions (such as pain, redness, and itching).

Side effects of Trokendi XR that are different from Emgality include tingling sensations in the arms and legs, dizziness, diarrhea, nausea, loss of appetite, changes in taste, weight loss, sleepiness, nervousness, memory problems, insomnia, depression, difficulty concentrating, anxiety, infections, drowsiness, weakness, numbness, psychomotor slowing, loss of coordination, bronchitis, confusion, mood changes, runny nose, leg pain, acne, constipation, rash, itching, dry mouth, urinary problems, chest pain, gastroesophageal reflux (GERD), anemia, and shortness of breath.

Emgality may interact with other drugs.

Trokendi XR may interact with alcohol, oral contraceptives, antiepileptic drugs, CNS depressants, carbonic anhydrase inhibitors, metformin, and lithium.

Common side effects of Emgality include:

• injection site reactions such as pain, redness, and itching

Common side effects of Trokendi XR include:

• tingling sensations in the arms and legs,
• dizziness,
• diarrhea,
• nausea,
• loss of appetite,
• changes in taste,
• weight loss,
• sleepiness,
• nervousness,
• memory problems,
• insomnia,
• depression,
• difficulty concentrating,
• anxiety,
• infections,
• drowsiness,
• weakness,
• numbness,
• psychomotor slowing,
• loss of coordination,
• bronchitis,
• confusion,
• mood changes,
• runny nose,
• leg pain,
• acne,
• constipation,
• rash,
• itching,
• dry mouth,
• urinary problems,
• chest pain,
• gastroesophageal reflux (GERD),
• anemia, and
• shortness of breath.

A small percent of patients taking Trokendi XR may experience suicidal ideation. If you have thoughts of suicide, tell your doctor immediately.

Emgality (galcanezumab-gnlm) is a calcitonin-gene related peptide antagonist indicated for the preventive treatment of migraine in adults.

Trokendi XR (topiramate) Extended-release is a sulfamate-substituted monosaccharide used as initial monotherapy in patients 10 years of age and older with partial onset or primary generalized tonic-clonic seizures and adjunctive therapy in patients 6 years of age and older with partial onset or primary generalized tonic-clonic seizures.

Emgality may interact with other drugs. Tell your doctor all medications and supplements you use.

Trokendi XR may interact with other seizure medications, other medicines that can make you sleepy (cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for depression or anxiety), metformin, and lithium.

Trokendi XR may also interact with alcohol, oral contraceptives, and carbonic anhydrase inhibitors.

The recommended dosage of Emgality is a 240 mg loading dose (administered as two consecutive injections of 120 mg each), followed by monthly doses of 120 mg.

The recommended dose for Trokendi XR monotherapy in adults and pediatric patients 10 years of age and older is 400 mg orally once daily.