Dayvigo vs. Sonata

• Dayvigo (lemborexant) and Sonata (zaleplon) are used to treat insomnia.
• Dayvigo and Sonata belong to different drug classes.
  • Dayvigo is an orexin receptor antagonist and
  • Sonata is a non-benzodiazepine sedative-hypnotic.
• Side effects of Dayvigo and Sonata that are similar include drowsiness and headache.
• Side effects of Dayvigo that are different from Sonata include nightmares or abnormal dreams.
• Side effects of Sonata that are different from Dayvigo include dizziness, short-term memory loss, problems with memory or concentration, lack of coordination (especially during the first 2 hours after you take the medication), "hangover" feeling, numbness or tingling, anxiety, depression, nervous feeling, problems with vision, nausea, stomach pain, loss of appetite, constipation, dry mouth, increased menstrual pain (cramps), back pain, joint or muscle pain, and mild skin rash.
• Both Dayvigo and Sonata may interact with alcohol and rifampin.
• Dayvigo may also interact with itraconazole, clarithromycin, fluconazole, verapamil, carbamazepine, St. John's wort, bosentan, efavirenz, etravirine, modafinil, chlorzoxazone, ranitidine, bupropion, and methadone.
• Sonata may also interact with cimetidine, thioridazine, promethazine, cyclosporine, antibiotics, antidepressants, narcotic pain medications, muscle relaxers, seizure medications, and anti-anxiety medications.
• Withdrawal symptoms may occur if you stop taking Sonata.

Common side effects of Dayvigo include:

• drowsiness,
• headache, and
• nightmares or abnormal dreams

Common side effects of Sonata include:

• dizziness,
• drowsiness,
• short-term memory loss,
• problems with memory or concentration,
• lack of coordination (especially during the first 2 hours after you take the medication),
• "hangover" feeling,
• numbness or tingling,
• anxiety,
• depression,
• nervous feeling,
• problems with vision,
• headache,
• nausea,
• stomach pain,
• loss of appetite,
• constipation,
• dry mouth,
• increased menstrual pain (cramps),
• back pain,
• joint or muscle pain, or
• mild skin rash.

Taking Sonata properly just before falling asleep will reduce your risk of these effects. Some people using Sonata have engaged in activities such as driving, eating, or making phone calls and later having no memory of the activity. If this happens to you, stop taking Sonata and talk with your doctor about another treatment for your sleep disorder. Tell your doctor if you have unlikely but serious side effects of Sonata including:

• mental/mood changes (e.g., agitation, confusion, seeing or hearing things that are not there, rare thoughts of suicide), or
• unusual behavior.

Dayvigo (lemborexant) is an orexin receptor antagonist used to treat adult patients with insomnia, characterized by difficulties with sleep onset and/or sleep maintenance.

Sonata (zaleplon) is a non-benzodiazepine sedative-hypnotic drug used to treat insomnia.

Dayvigo may interact with other medicines such as:

• itraconazole,
• clarithromycin,
• fluconazole,
• verapamil,
• rifampin,
• carbamazepine,
• St. John’s wort,
• bosentan,
• efavirenz,
• etravirine,
• modafinil,
• alcohol,
• bupropion, and
• methadone

Tell your doctor about all medications and supplements you use.

Sonata may interact with cimetidine, thioridazine, promethazine, cyclosporine, rifampin, antibiotics, antidepressants, narcotic pain medications, muscle relaxers, seizure medications, or anti-anxiety medications.

• The recommended dose of Dayvigo is 5 mg taken no more than once per night, immediately before going to bed, with at least 7 hours remaining before the planned time of awakening.
• The dosage of Dayvigo may be increased to 10 mg based on clinical response and tolerability.

The dose of Sonata should be individualized.

• The recommended dose for most adults is 10 mg.
• For some patients, 5 mg may be a sufficient dose.