Dayvigo vs. Ambien

• Dayvigo (lemborexant) and Ambien (zolpidem) are used to treat insomnia.
• Dayvigo and Ambien belong to different drug classes.
  • Dayvigo is an orexin receptor antagonist and
  • Ambien is a sedative/hypnotic.
• Side effects of Dayvigo and Ambien that are similar include drowsiness and headache.
• Side effects of Dayvigo that are different from Ambien include nightmares or abnormal dreams.
• Side effects of Ambien that are different from Dayvigo include dizziness, weakness, lightheadedness, "drugged" feeling, tiredness, loss of coordination, stuffy nose, nasal irritation, dry mouth, sore throat, nausea, constipation, diarrhea, stomach upset,
• muscle pain, confusion, insomnia, euphoria, balance problems, and visual changes.
• Both Dayvigo and Ambien may interact with alcohol, itraconazole, rifampin, and antidepressants.
• Dayvigo may also interact with clarithromycin, fluconazole, verapamil, carbamazepine, St. John's wort, bosentan, efavirenz, etravirine, modafinil, chlorzoxazone, ranitidine, bupropion, and methadone.
• Ambien may also interact with other medicines that make you sleepy or slow your breathing (such as cold medicines, pain medications, muscle relaxants, and medicines for anxiety or seizures), chlorpromazine, and ketoconazole.
• Ambien can cause withdrawal symptoms (muscle cramps, sweats, shaking, and seizures).

Common side effects of Dayvigo include:

• Drowsiness,
• Headache, and
• Nightmares or abnormal dreams

Common side effects of Ambien include:

• Daytime drowsiness,
• Dizziness,
• Weakness,
• Lightheadedness,
• "Drugged" feeling,
• Tiredness,
• Loss of coordination,
• Stuffy nose,
• Nasal irritation,
• Dry mouth,
• Sore throat,
• Nausea,
• Constipation,
• Diarrhea,
• Stomach upset,
• Headache,
• Muscle pain,
• Confusion,
• Insomnia,
• Euphoria,
• Ataxia (balance problems), and
• Visual changes.

Tell your doctor if you have unlikely but serious side effects of Ambien including:

• memory loss,
• mental/mood/behavior changes (such as new or worsening depression, abnormal thoughts, thoughts of suicide, hallucinations, confusion, agitation, aggressive behavior, or anxiety).

Dayvigo (lemborexant) is an orexin receptor antagonist used to treat adult patients with insomnia, characterized by difficulties with sleep onset and/or sleep maintenance.

Ambien (zolpidem) is a sedative/hypnotic used for treating insomnia.

Dayvigo may interact with other medicines such as:

• itraconazole,
• clarithromycin,
• fluconazole,
• verapamil,
• rifampin,
• carbamazepine,
• St. John’s wort,
• bosentan,
• efavirenz,
• etravirine,
• modafinil,
• alcohol,
• bupropion, and
• methadone

Tell your doctor all medications and supplements you use.

• Ambien may interact with other medicines that make you sleepy or slow your breathing (such as cold medicines, pain medications, muscle relaxants, and medicines for depression, anxiety, or seizures) or antidepressants.
• Ambien may also interact with alcohol, chlorpromazine, itraconazole, ketoconazole, or rifampin.
• Insomnia symptoms may also return after you stop taking Ambien.
  • These symptoms may seem to be worse than before you started taking Ambien.

• The recommended dose of Dayvigo is 5 mg taken no more than once per night, immediately before going to bed, with at least 7 hours remaining before the planned time of awakening.
• The dosage of Dayvigo may be increased to 10 mg based on clinical response and tolerability.

The recommended adult dose of Ambien is

• 10 mg as conventional tablets or spray or
• 12.5 mg as extended-release tablets.