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Bivigam vs. Xembify

Are Bivigam and Xembify the Same Thing?

Bivigam [Immune Globulin Intravenous (Human), 10% Liquid] and Xembify (immune globulin subcutaneous, human–klhw) are immune globulins used to treat primary humoral immunodeficiency (PI).

Side effects of Bivigam and Xembify that are similar include infusion site reactions (redness, pain, swelling, bruising, hard lump itching, firmness, scabbing), and diarrhea.

Side effects of Bivigam that are different from Xembify include headache, fatigue, nausea, sinus infection, increased blood pressure, dizziness, tiredness, back pain, migraine, muscle pain, and sore throat.

Side effects of Xembify that are different from Bivigam include cough.

Both Bivigam and Xembify may interact with live virus vaccines, such as measles, mumps, rubella, and varicella.

What Are Possible Side Effects of Bivigam?

Common side effects of Bivigam include:

  • headache
  • fatigue
  • infusion site reaction
  • nausea
  • sinus infection
  • increased blood pressure
  • diarrhea
  • dizziness
  • tiredness
  • back pain
  • migraine
  • muscle pain, and
  • sore throat

What Are Possible Side Effects of Xembify?

Common side effects of Xembify include:

  • infusion site reactions (redness, pain, swelling, bruising, hard lump itching, firmness, scabbing),
  • cough, and
  • diarrhea

What Is Bivigam?

Bivigam [Immune Globulin Intravenous (Human), 10% Liquid] is an immune globulin used to treat primary humoral immunodeficiency (PI).

What Is Xembify?

Xembify (immune globulin subcutaneous, human–klhw) is a 20% immune globulin olution for subcutaneous injection indicated for treatment of Primary Humoral Immunodeficiency (PI) in patients 2 years of age and older.

What Drugs Interact With Bivigam?

Bivigam may interfere with the immune response to live virus vaccines, such as measles, mumps, rubella, and varicella. Tell your doctor all vaccines you recently received. Renal dysfunction, acute renal failure and death may occur with the administration of Bivigam in predisposed patients. Doctors should closely monitor the kidney function of patients who receive Bivigam. The use of Bivigam in pregnant women has not been studied. The use of Bivigam in nursing mothers has not been studied and it should only be given to a nursing woman if clearly needed.

What Drugs Interact With Xembify?

Xembify may interact with live virus vaccines, such as measles, mumps, rubella, and varicella. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Xembify; it is unknown how it would affect a fetus. It is unknown if Xembify passes into breast milk. Consult your doctor before breastfeeding.

How Should Bivigam Be Taken?

Bivigam is a liquid solution containing 10% IgG (100mg/mL) given intravenously (IV).

How Should Xembify Be Taken?

The dose of Xembify is individualized based on the patient's pharmacokinetic and clinical response.

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