Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Epidermolysis bullosa simplex
Medically reviewed by Min Clinic Staff | Updated: January 2026
Epidermolysis bullosa simplex: A variant of epidermolysis bullosa.
Epidermolysis bullosa simplex (EBS) usually begins with blistering that is evident at birth or shortly afterward. In a localized, mild form of EBS called Weber-Cockayne, blisters rarely extend beyond the feet and hands. In some subtypes of EBS, the blisters occur over widespread areas of the body.