Definition of Mediastinum Mediastinum: The area between the lungs. The organs in the mediastinum include the heart and its large veins and arteries, the trachea, the esophagus, the bronchi, and lymph nodes.
Mediastinum: The area between the lungs. The organs in the mediastinum include the heart and its large veins and arteries, the trachea, the esophagus, the bronchi, and lymph nodes.