Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Pseudomelanosis coli
Medically reviewed by Min Clinic Staff | Updated: January 2026
Pseudomelanosis coli: A benign, reversible condition usually, but not always, associated with long-term use of anthranoid laxatives in which pigment deposition in the lamina propria of the large intestine results in a brown to black discoloration of the mucosa (lining) of the large intestine. Melanosis coli produces no symptoms and is indicative of chronic senna laxative use.