Definition of Parkinson disease gene

Parkinson disease gene: A gene involved in the causation of Parkinson disease. There are a number of different autosomal dominant and recessive forms of Parkinson disease.

They are called PARK1, PARK2, and so on:

• PARK1 is an autosomal dominant trait and is due to mutation in the alpha-synuclein gene (SNCA) on chromosome 4q21;
• PARK2 is an autosomal recessive trait and is due to mutation in the gene encoding parkin on chromosome 6q25.2-q27;
• PARK3 is an autosomal dominant trait and is due to a gene on chromosome 2p13;
• PARK4 is an autosomal dominant trait and is due to a gene on chromosome 4p15;
• PARK5 is an autosomal dominant trait and is due to mutation in the UCHL1 gene on chromosome 4p14;
• PARK6 is an autosomal recessive trait and is due to mutation in a gene on chromosome 1p distinct from DJ1;
• PARK7 is an autosomal recessive trait and is due to mutation in the DJ1 gene on 1p36;
• PARK8 is an autosomal dominant trait and is due to a gene on chromosome 12p11.2-q13.1;
• PARK9 is an autosomal recessive trait and is due to a gene on chromosome 1p36;
• PARK10 is an autosomal dominant trait and is due to a gene on chromosome 1p;
• PARK11 is an autosomal dominant trait and is due to a gene on chromosome 2q.

People in an Iowa family affected with an early-onset autosomal dominant form of Parkinson disease have a triplication of the alpha-synuclein gene (SNCA) on chromosome 4q21. This may be another genetic route to PARK1.