Duract: Full Drug Profile
Duract - General Information
Duract is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool to optimize surgical outcomes.
Pharmacology of Duract
Duract ophthalmic solution is a sterile, topical, nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use.
Duract for patients
XIBROM ophthalmic solution should not be administered while wearing contact lenses.
Duract Interactions
No information provided.
Duract Contraindications
XIBROM ophthalmic solution is contraindicated in patients with known hypersensitivity to any ingredient in the formulation.
Additional information about Duract
- Duract Indication
For the treatment of postoperative inflammation in patients who have undergone cataract extraction.
- Mechanism Of Action
- The mechanism of its action is thought to be due to its ability to block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2. Prostaglandins have been shown in many animal models to be mediators of certain kinds of intraocular inflammation. In studies performed in animal eyes, prostaglandins have been shown to produce disruption of the blood-aqueous humor barrier, vasodilation, increased vascular permeability, leukocytosis, and increased intraocular pressure.
- Generic Name
- Bromfenac
- Synonyms
- Bromfenac sodium
- Drug Category
- Analgesics; Anti-Inflammatory Agents, Non-Steroidal
- Drug Type
- Small Molecule; Approved
- Other Brand Names containing Bromfenac
- Xibrom; Duract;
- Absorption
- The plasma concentration of bromfenac following ocular administration in humans is unknown.
- Dosage Forms of Duract
- Solution / drops Ophthalmic
- Chemical IUPAC Name
- 2-[2-amino-3-(4-bromobenzoyl)phenyl]acetic acid
- Chemical Formula
- C15H12BrNO3
- Organisms Affected
- Humans and other mammals