Disoprivan
Disoprivan - General Information
An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206)
Pharmacology of Disoprivan
Disoprivan a sedative-hypnotic agent for use in the induction and maintenance of anesthesia or sedation. Intravenous injection of a therapeutic dose of propofol produces hypnosis rapidly with minimal excitation, usually within 40 seconds from the start of an injection (the time for one arm-brain circulation).
Disoprivan for patients
Patients should be advised that performance of activities requiring mental alertness, such as operating a motor vehicle or hazardous machinery or signing legal documents may be impaired for some time after general anesthesia or sedation.
Disoprivan Interactions
The induction dose requirements of DIPRIVAN Injectable Emulsion may be reduced in patients with intramuscular or intravenous premedication, particularly with narcotics (eg, morphine, meperidine, and fentanyl, etc.) and combinations of opioids and sedatives (eg, benzodiazepines, barbiturates, chloral hydrate, droperidol, etc.). These agents may increase the anesthetic or sedative effects of DIPRIVAN Injectable Emulsion and may also result in more pronounced decreases in systolic, diastolic, and mean arterial pressures and cardiac output.
During maintenance of anesthesia or sedation, the rate of DIPRIVAN Injectable Emulsion administration should be adjusted according to the desired level of anesthesia or sedation and may be reduced in the presence of supplemental analgesic agents (eg, nitrous oxide or opioids). The concurrent administration of potent inhalational agents (eg, isoflurane, enflurane, and halothane) during maintenance with DIPRIVAN Injectable Emulsion has not been extensively evaluated. These inhalational agents can also be expected to increase the anesthetic or sedative and cardiorespiratory effects of DIPRIVAN Injectable Emulsion.
DIPRIVAN Injectable Emulsion does not cause a clinically significant change in onset, intensity, or duration of action of the commonly used neuromuscular blocking agents (eg, succinylcholine and nondepolarizing muscle relaxants).
No significant adverse interactions with commonly used premedications or drugs used during anesthesia or sedation (including a range of muscle relaxants, inhalational agents, analgesic agents, and local anesthetic agents) have been observed.
Disoprivan Contraindications
DIPRIVAN Injectable Emulsion is contraindicated in patients with a known hypersensitivity to DIPRIVAN Injectable Emulsion or its components, or when general anesthesia or sedation are contraindicated.
Additional information about Disoprivan
Disoprivan Indication: Used for both induction and/or maintenance of anesthesia.
Mechanism Of Action: The action of propofol involves a positive modulation of the inhibitory function of the neurotransmitter gama-aminobutyric acid(GABA) through GABA-A receptors.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Propofol
Synonyms: 2,6-Diisopropylphenol; Diisopropylphenol
Drug Category: Anesthetics, Intravenous; Anticonvulsants; Antiemetics; Free Radical Scavengers; Hypnotics and Sedatives
Drug Type: Small Molecule; Approved
Other Brand Names containing Propofol: Diprivan; Disoprivan; Disoprofol; Rapinovet;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: 95 to 99%
Biotransformation: Hepatic
Half Life: Not Available
Dosage Forms of Disoprivan: Emulsion Intravenous
Chemical IUPAC Name: 2,6-di(propan-2-yl)phenol
Chemical Formula: C12H18O
Propofol on Wikipedia: https://en.wikipedia.org/wiki/Propofol
Organisms Affected: Humans and other mammals
