Dinolytic
Dinolytic - General Information
The tromethamine (THAM) salt of the naturally occurring prostaglandin F2 alpha, dinoprost tromethamine occurs as a white to off-white, very hygroscopic, crystalline powder. Dinoprost tromethamine may also be known as dinoprost trometamol, PGF2 alpha THAM, or prostaglandin F2 alpha tromethamine.
Pharmacology of Dinolytic
Dinoprost tromethamine is the tromethamine (THAM) salt of the naturally occurring prostaglandin F2alpha. Prostaglandin F2alpha has several pharmacologic effects on the female reproductive system, including stimulation of myometrial activity, relaxation of the cervix, inhibition of steroidogenesis by corpora lutea, and can potentially lyse corpora lutea.
Dinolytic for patients
Dinolytic Interactions
Oxytocin or other oxytocics (concurrent use with dinoprost may result in uterine hypertonus, possibly causing uterine rupture or cervical laceration, especially in the absence of adequate cervical dilatation; although combinations are sometimes used for therapeutic advantage, when used concurrently, patient should be closely monitored.
Dinolytic Contraindications
Allergy or intolerance to dinoprost or other oxytocics, asthma - or history of (increased risk of bronchoconstriction), cephalopelvic disproportion, pelvic inflammatory disease, pulmonary disease - active, and ruptured membranes — intra-amniotic or extra-amniotic route (increased risk of intravascular absorption of dinoprost).
Additional information about Dinolytic
Dinolytic Indication: Used for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities incompatible with life. Also used at low-doses for medically indicated induction of labor at term. Also injected intra-arterially for use as a vasodilator to assist in angiography.
Mechanism Of Action: Dinoprost tromethamine appears to act directly on the myometrium, but this has not been completely established. Dinoprost stimulates myometrial contractions in the gravid uterus that are similar to the contractions that occur in the term uterus during labor. These contractions are usually sufficient to cause abortion. Uterine response to prostaglandins increases gradually throughout pregnancy. Dinoprost also facilitates cervical dilatation and softening.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Dinoprost Tromethamine
Synonyms: Dinoprost, trometamol salt; PGF2-alpha THAM; PGF2alpha THAM; Prostaglandin F2-alpha THAM; Prostaglandin F2a tromethamine; Prostaglandin F2alpha tham; Prostin F2 Alpha
Drug Category: Abortifacient Agents, Nonsteroidal; Oxytocics; Diagnostic aid (angiography); Uterine stimulants
Drug Type: Small Molecule; Approved
Other Brand Names containing Dinoprost Tromethamine: Dinolytic; Ensaprost; Lutalyse; Panacelan F tromethamine salt; Pronalgon F; Prostalmon F; Zinoprost;
Absorption: Slowly absorbed from the amniotic fluid into systemic circulation.
Toxicity (Overdose): Although overdose by intra-amniotic administration of dinoprost has not been reported, exaggeration of the nausea, vomiting, and diarrhea that occur with normal doses would be expected.
Protein Binding: Not Available
Biotransformation: Enzymatic dehydrogenation primarily in the maternal lungs and also in the liver.
Half Life: The half-life of dinoprost in amniotic fluid is 3 to 6 hours. The plasma half-life of dinoprost after intravenous administration is reported to be less than 1 minute.
Dosage Forms of Dinolytic: Solution Intra-amniotic
Chemical IUPAC Name: 2-amino-2-(hydroxymethyl)propane-1,3-diol; (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid
Chemical Formula: C24H45NO8
Dinoprost Tromethamine on Wikipedia: Not Available
Organisms Affected: Humans and other mammals
