Dermatop
Dermatop - General Information
Dermatop is a relatively new topical corticosteroid drug. It is similar in potency to hydrocortisone. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a low potential to cause skin atrophy. The anti-inflammation action of corticosteroids is associated with the inhibition of the interleukin 1-alpha cytokine within keratinocytes. IL-1a is also found in fibroblasts, where it is responsible for proliferation, collagenase induction and IL-6 synthesis, which are related to skin thickness.
Pharmacology of Dermatop
Corticosteroids diffuse across cell membranes and complex with specific cytoplasmic receptors. These complexes then enter the cell nucleus, bind to DNA (chromatin), and stimulate transcription of messenger RNA (mRNA) and subsequent protein synthesis of various inhibitory enzymes responsible for the anti-inflammatory effects of topical corticosteroids. These anti-inflammatory effects include inhibition of early processes such as edema, fibrin deposition, capillary dilatation, movement of phagocytes into the area, and phagocytic activities. Later processes, such as capillary production, collagen deposition, and keloid formation also are inhibited by corticosteroids.
Dermatop for patients
Dermatop Interactions
No Information Provided.
Dermatop Contraindications
DERMATOP Emollient Cream 0.1% is contraindicated in those patients with a history of hypersensitivity to any of the components in the preparations.
Additional information about Dermatop
Dermatop Indication: For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Mechanism Of Action: In common with other topical corticosteroids, prednicarbate has anti-inflammatory, antipruritic, and vasoconstrictive properties. In general, the mechanism of the anti-inflammatory activity of topical steroids is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Prednicarbate
Synonyms: Not Available
Drug Category: Corticosteroid; Anti Inflammatory; Steroidal
Drug Type: Small Molecule; Approved
Other Brand Names containing Prednicarbate: Dermatop; Dermatop E Emollient;
Absorption: Absorbed systemically across the stratum corneum.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Primarily in skin
Half Life: Not Available
Dosage Forms of Dermatop: Liquid Intradermal
Liquid Cutaneous
Liquid Subcutaneous
Ointment Topical
Cream Topical
Chemical IUPAC Name: [2-(17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl] propanoate
Chemical Formula: C27H36O8
Prednicarbate on Wikipedia: https://en.wikipedia.org/wiki/Prednicarbate
Organisms Affected: Humans and other mammals