Decabid: Full Drug Profile

Decabid - General Information

Decabid is a rarely used antidysrhythmic. Decabid has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.

Pharmacology of Decabid

Decabid is a rarely used antidysrhythmic. Decabid has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.

Decabid for patients

Decabid Interactions

Decabid Contraindications

Contraindicated in right bundle branch block, cardiogenic shock, hypersensitivity, and second or third degree AV block.

Additional information about Decabid

Decabid Indication

For the treatment of life-threatening dysrhythmias and sustained ventricular tachycardia.

Mechanism Of Action

Decabid acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.

Generic Name

Indecainide

Synonyms

Ricainid; Ricainide; Indecainidum [Latin]; Indecainida [Spanish]; 9-(3-(Isopropylamino)propyl)-9-fluorenylcarboxamid; 9-(3-(Isopropylamino)propyl))fluorene-9-carboxamide

Drug Category

Antidysrhythmic Agents; Sodium channel blockers

Drug Type

Small Molecule; Approved

Other Brand Names containing Indecainide

Decabid;

Absorption

Nearly complete following oral administration.

Toxicity (Overdose)

When given orally to either young adult rats or mice, the LD50 was 100 mg/kg. Symptoms of overdose include nausea and vomiting, convulsions, hypotension, bradycardia, syncope, extreme widening of the QRS complex, widening of the QT interval, widening of the PR interval, ventricular tachycardia, AV nodal block, asystole, bundle branch block, cardiac failure, and cardiac arrest.

Chemical IUPAC Name

9-[3-(propan-2-ylamino)propyl]fluorene-9-carboxamide

Chemical Formula

C20H24N2O

Organisms Affected

Humans and other mammals