Cyclapen

Cyclapen - General Information

A cyclohexylamido analog of penicillanic acid. [PubChem]

Pharmacology of Cyclapen

Cyclapen, a penicillin, is a cyclohexylamido analog of penicillanic acid. Cyclapen is more resistant to beta-lactamase hydrolysis than ampicillin, is much better absorbed when given by mouth and, as a result, the levels reached in the blood and in the urine are considerably higher than those obtained with the same dose of ampicillin. Cyclapen has been replaced by newer penicillin treatments.

Additional information about Cyclapen

Cyclapen Indication: For the treatment of bacterial infections caused by susceptible organisms.
Mechanism Of Action: The bactericidal activity of cyclacillin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cyclapen is stable in the presence of a variety of b-lactamases, including penicillinases and some cephalosporinases.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Cyclacillin
Synonyms: Ciclacilline [INN-French]; Ciclacillinum [INN-Latin]; Ciclacilina [INN-Spanish]; Aminocyclohexylpenicillin; Ciclacillin; Ciclacillum
Drug Category: Anti-Bacterial Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Cyclacillin: Bastcillin; Calthor; Citosarin; Cyclapen; Cyclapen-W; Orfilina; Syngacillin; Ultracillin; Vastcillin; Vipicil; Wyvital;
Absorption: Moderately absorbed.
Toxicity (Overdose): Symptoms of overdose include severe diarrhea, nausea and vomiting.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Cyclapen: Not Available
Chemical IUPAC Name: (2S,5R,6R)-6-[(1-aminocyclohexanecarbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Chemical Formula: C15H23N3O4S
Cyclacillin on Wikipedia: Not Available
Organisms Affected: Enteric bacteria and other eubacteria