Corlopam
Corlopam - General Information
A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.
Pharmacology of Corlopam
Corlopam antagonizes D1-like dopamine receptors, binds to α2-adrenoceptors, increasing renal blood flow.
Corlopam for patients
Corlopam Interactions
Drug Interactions with Beta-Blockers: Concomitant use of fenoldopam with beta-blockers should be avoided. If the drugs are used together, caution should be exercised because unexpected hypotension could result from beta-blocker inhibition of the sympathetic reflex response to fenoldopam.
Drug Interactions, General: Although there have been no formal interaction studies, intravenous fenoldopam has been administered safely with drugs such as digitalis and sublingual nitroglycerin. There is limited experience with concomitant antihypertensive agents such as alpha-blockers, calcium channel-blockers, ACE inhibitors, and diuretics (both thiazide-like and loop).
Corlopam Contraindications
None known.
Additional information about Corlopam
Corlopam Indication: For the in-hospital, short-term (up to 48 hours) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function.
Mechanism Of Action: Corlopam is a rapid-acting vasodilator. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and β-adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Corlopam is a racemic mixture with the R-isomer responsible for the biological activity. The R-isomer has approximately 250-fold higher affinity for D1-like receptors than does the S-isomer. In non-clinical studies, fenoldopam had no agonist effect on presynaptic D2-like dopamine receptors, or α or β -adrenoceptors, nor did it affect angiotensin-converting enzyme activity. Corlopam may increase norepinephrine plasma concentration.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Fenoldopam
Synonyms: Fenodopam mesylate; Fenoldopam mesylate; Fenoldopamum [Latin]
Drug Category: Antihypertensive Agents; Dopamine Agonists; Vasodilator Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Fenoldopam: Corlopam;
Absorption: Not Available
Toxicity (Overdose): The most likely reaction of overdose would be excessive hypotension which should be treated with drug discontinuation and appropriate supportive measures.
Protein Binding: Not Available
Biotransformation: Elimination is largely by conjugation, without participation of cytochrome P-450 enzymes. Methylation, glucuronidation, and sulfation are the main routes of conjugation.
Half Life: The elimination half-life is about 5 minutes in mild to moderate hypertensives, with little difference between the R (active) and S isomers.
Dosage Forms of Corlopam: Injection, solution Intravenous drip
Chemical IUPAC Name: 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
Chemical Formula: C16H16ClNO3
Fenoldopam on Wikipedia: https://en.wikipedia.org/wiki/Fenoldopam
Organisms Affected: Humans and other mammals
