Codicept
Codicept - General Information
An opioid analgesic related to morphine but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.
Pharmacology of Codicept
Codicept, an opiate agonist in the CNS, is similar to other phenanthrene derivatives such as morphine. Codicept, in combination with guaifenesin or iodinated glycerol, is used as a cough suppressant and, as a single agent or in combination with acetaminophen or other products, is used for pain control and as an antidiarrheal agent.
Codicept for patients
Codeine may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, s.c. as driving a car or operating machinery. Codeine in combination with other narcotic analgesics, phenothiazines, sedative hypnotics, and alcohol has additive depressant effects.
Codicept Interactions
Codeine in combination with other narcotic analgesics, general anesthetics, phenothiazines, tranquilizers, sedative-hypnotics, or other CNS depressants (including alcohol) has additive depressant effects. When s.c. combination therapy is contemplated, the dosage of one or both agents should be reduced.
Codicept Contraindications
Hypersensitivity to codeine.
Additional information about Codicept
Codicept Indication: For treatment and management of pain (Systemic), also used as an Antidiarrheal and as a cough suppressant.
Mechanism Of Action: Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Codicept's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Drug Interactions: Cimetidine Cimetidine increases the effect of the narcotic
Dihydroquinidine barbiturate Quinidine decreases the analgesic effect of codeine
Naltrexone Naltrexone may precipitate a withdrawal syndrome in opioid-dependent individual
Quinidine Quinidine decreases the analgesic effect of codeine
Quinidine barbiturate Quinidine decreases the analgesic effect of codeine
Food Interactions: Avoid alcohol.
Take with food, food reduces irritation.
To avoid constipation: increase your daily intake of fiber (beans, whole grains, vegetables).
Generic Name: Codeine
Synonyms: Codeine anhydrous; L-Codeine; Methylmorphine; Morphine monomethyl ether; Norcodeine, N-Methyl; Norcodine, N-Methyl
Drug Category: Narcotics; Antitussives; Analgesics; Opiate Agonists
Drug Type: Small Molecule; Illicit; Approved
Other Brand Names containing Codeine: Codicept; Coducept;
Absorption: Well absorbed following oral administration with a bioavailability of approximately 90%.
Toxicity (Overdose): Respiratory depression, sedation and miosis and common symptoms of overdose. Other symptoms include nausea, vomiting, skeletal muscle flaccidity, bradycardia, hypotension, and cool, clammy skin. Apnea and death may ensue.
Protein Binding: 7-25%
Biotransformation: Hepatic. Codeine is a prodrug, itself inactive, but demethylated to the active morphine by the liver enzyme CYP2D6.
Half Life: 2-4 hours
Dosage Forms of Codicept: Liquid Oral
Tablet Oral
Syrup Oral
Liquid Intramuscular
Solution Intramuscular
Chemical IUPAC Name: (5(,6()-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
Chemical Formula: C18H21NO3
Codeine on Wikipedia: https://en.wikipedia.org/wiki/Codeine
Organisms Affected: Humans and other mammals
