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Choloxin: Full Drug Profile

Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026

Choloxin - General Information

The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism.

 

Pharmacology of Choloxin

Choloxin, the dextrorotary isomer of the synthetic thyroxine, is a antihyperlipidemic.

 

Additional information about Choloxin

Choloxin Indication: Used to lower high cholesterol levels in the blood. Mechanism Of Action: Choloxin is a antihyperlipidemic. The mechanism of action is not completely understood, but dextrothyroxine apparently acts in the liver to stimulate formation of low-density lipoprotein (LDL) and, to a much greater extent, to increase catabolism of LDL. This leads to increased excretion of cholesterol and bile acids via the biliary route into the feces, with a resulting reduction in serum cholesterol and LDL. Choloxin has no significant effect on high-density lipoproteins (HDL). Drug Interactions: Anisindione Thyroid hormones increase the anticoagulant effect Dicumarol Thyroid hormones increase the anticoagulant effect Digoxin The thyroid hormone decreases the effect of digoxin Warfarin Thyroid hormones increase the anticoagulant effect Acenocoumarol Thyroid hormones increase the anticoagulant effect Food Interactions: Take without regard to meals. Generic Name: Dextrothyroxine Synonyms: Not Available Drug Category: Antihyperlipidemics Drug Type: Small Molecule; Approved Other Brand Names containing Dextrothyroxine: Choloxin; Absorption: Not Available Toxicity (Overdose): Symptoms of dextrothyroxine overdose are unknown. Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Choloxin: Powder, for solution Intravenous Tablet Oral Chemical IUPAC Name: 2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid Chemical Formula: C15H11I4NO4 Dextrothyroxine on Wikipedia: https://en.wikipedia.org/wiki/Dextrothyroxine Organisms Affected: Humans and other mammals