Choloxin
Choloxin - General Information
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism.
Pharmacology of Choloxin
Choloxin, the dextrorotary isomer of the synthetic thyroxine, is a antihyperlipidemic.
Additional information about Choloxin
Choloxin Indication: Used to lower high cholesterol levels in the blood.
Mechanism Of Action: Choloxin is a antihyperlipidemic. The mechanism of action is not completely understood, but dextrothyroxine apparently acts in the liver to stimulate formation of low-density lipoprotein (LDL) and, to a much greater extent, to increase catabolism of LDL. This leads to increased excretion of cholesterol and bile acids via the biliary route into the feces, with a resulting reduction in serum cholesterol and LDL. Choloxin has no significant effect on high-density lipoproteins (HDL).
Drug Interactions: Anisindione Thyroid hormones increase the anticoagulant effect
Dicumarol Thyroid hormones increase the anticoagulant effect
Digoxin The thyroid hormone decreases the effect of digoxin
Warfarin Thyroid hormones increase the anticoagulant effect
Acenocoumarol Thyroid hormones increase the anticoagulant effect
Food Interactions: Take without regard to meals.
Generic Name: Dextrothyroxine
Synonyms: Not Available
Drug Category: Antihyperlipidemics
Drug Type: Small Molecule; Approved
Other Brand Names containing Dextrothyroxine: Choloxin;
Absorption: Not Available
Toxicity (Overdose): Symptoms of dextrothyroxine overdose are unknown.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Choloxin: Powder, for solution Intravenous
Tablet Oral
Chemical IUPAC Name: 2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
Chemical Formula: C15H11I4NO4
Dextrothyroxine on Wikipedia: https://en.wikipedia.org/wiki/Dextrothyroxine
Organisms Affected: Humans and other mammals
