Chlodithane

Chlodithane - General Information

A derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

Pharmacology of Chlodithane

Chlodithane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Chlodithane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inhibition, apparently without cellular destruction. The administration of Chlodithane alters the extra-adrenal metabolism of cortisol in man; leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma levels of corticosteroids do not fall. The drug apparently causes increased formation of 6-B-hydroxyl cortisol.

Chlodithane for patients

PATIENT INFORMATION
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Chlodithane Interactions

Mitotane has been reported to accelerate the metabolism of warfarin by the mechanism of hepatic microsomal enzyme induction, leading to an increase in dosage requirements for warfarin. Therefore, physicians should closely monitor patients for a change in anticoagulant dosage requirements when administering Mitotane to patients on coumarin-type anticoagulants. In addition, Mitotane should be given with caution to patients receiving other drugs susceptible to the influence of hepatic enzyme induction.

Chlodithane Contraindications

Mitotane should not be given to individuals who have demonstrated a previous hypersensitivity to it.

Additional information about Chlodithane

Chlodithane Indication: For treatment of inoperable adrenocortical tumours; Cushing's syndrome
Mechanism Of Action: Its biochemical mechanism of action is unknown, although data are available to suggest that the drug modifies the peripheral metabolism of steroids as well as directly suppressing the adrenal cortex.
Drug Interactions: Anisindione Chlodithane decreases the anticoagulant effect
Acenocoumarol Chlodithane decreases the anticoagulant effect
Warfarin Chlodithane decreases the anticoagulant effect
Dicumarol Chlodithane decreases the anticoagulant effect
Spironolactone Spironolactone antagonizes the effect of mitotane
Food Interactions: Not Available
Generic Name: Mitotane
Synonyms: Not Available
Drug Category: Antineoplastic Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Mitotane: Chloditan; Chlodithan; Chlodithane; Khlodithan; Lysodren; Mitotan; Mitotanum [INN-Latin];
Absorption: About 40% oral Lysodren is absorbed
Toxicity (Overdose): Not Available
Protein Binding: 6%
Biotransformation: Hepatic and renal
Half Life: 18-159 days
Dosage Forms of Chlodithane: Tablet Oral
Chemical IUPAC Name: 1-chloro-4-[2,2-dichloro-1-(2-chlorophenyl)ethyl]benzene
Chemical Formula: C14H10Cl4
Mitotane on Wikipedia: https://en.wikipedia.org/wiki/Mitotane
Organisms Affected: Humans and other mammals