Canderel
Canderel - General Information
Flavoring agent sweeter than sugar, metabolized as phenylalanine and aspartic acid.
Pharmacology of Canderel
Canderel (L-alpha-aspartyl-L-phenylalanine methyl ester) is a low-calorie sweetener used to sweeten a wide variety of low- and reduced-calorie foods and beverages, including low-calorie tabletop sweeteners. Canderel is composed of two amino acids, aspartic acid and phenylalanine, as the methyl ester. Aspartic acid and phenylalanine are also found naturally in protein containing foods, including meats, grains and dairy products. Methyl esters are also found naturally in many foods such as fruits and vegetable and their juices. Upon digestion, aspartame breaks down into three components (aspartic acid, phenylalanine and methanol), which are then absorbed into the blood and used in normal body processes. Neither aspartame nor its components accumulates in the body. These components are used in the body in the same ways as when they are derived from common foods.
Additional information about Canderel
Canderel Indication: Used as a diet supplement and sugar substitute.
Mechanism Of Action: 180 to 200 times sweeter than sucrose, it is metabolized as a protein and its subsequent amino-acids used up in there respective mechanisms.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Aspartame
Synonyms: Aspartam [INN-French]; Asp-phe-ome; Aspartame [USAN-BAN-INN]; APM; Aspartamo [INN-Spanish]; Aspartamum [INN-Latin]; Aspartylphenylalanine methyl ester; 1-Methyl N-L-alpha-aspartyl-L-phenylalanate; 3-Amino-N-(alpha-methoxycarbonylphenethyl) succinamic acid; 3-Amino-N-(alpha-carboxyphenethyl)succinamic acid N-methyl ester, stereoisomer; 3-Amino-N-(alpha-carboxyphenethyl)succinamic acid N-methyl ester; 1-Methyl N-L-alpha-aspartyl-L-phenylalanine; N-L-alpha-Aspartyl-L-phenylalanine 1-methyl ester; Methyl N-L-alpha-aspartyl-L-phenylalaninate; Methyl L-aspartyl-L-phenylalanine; Methyl L-alpha-aspartyl-L-phenylalanate; Methyl aspartylphenylalanate; L-Aspartyl-L-phenylalanine methyl ester; Dipeptide sweetener; Sweet dipeptide
Drug Category: Dietary supplement; Micronutrient
Drug Type: Small Molecule; Nutraceutical; Approved
Other Brand Names containing Aspartame: Canderel; Equal; Nutrasweet; Tri-sweet;
Absorption: Absorbed in the small intestine, aspartame is metabolized and absorbed very quickly.
Toxicity (Overdose): Mild gastrointestinal side effects including diarrhea have been reported.
Protein Binding: Not Available
Biotransformation: Approximately 10% of aspartame (by weight) is broken down into methanol in the small intestine. Most of the methanol is absorbed and quickly converted into formaldehyde. Approximately 50% of aspartame (by weight) is broken down into phenylalanine. Approximately 40% of aspartame (by mass) is broken down into aspartic acid.
Half Life: At room temperature, aspartame is most stable at pH 4.3, where its half-life is nearly 300 days. At pH 7 however, its half-life is only a few days.
Dosage Forms of Canderel: Not Available
Chemical IUPAC Name: 3-amino-4-[(1-methoxy-1-oxo-3-phenylpropan-2-yl)amino]-4-oxobutanoic acid
Chemical Formula: C14H18N2O5
Aspartame on Wikipedia: https://en.wikipedia.org/wiki/Aspartame
Organisms Affected: Humans and other mammals
