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Bactocill: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Bactocill - General Information

An antibiotic similar to flucloxacillin used in resistant staphylococci infections.

 

Pharmacology of Bactocill

Bactocill is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Bactocill has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Bactocill results from the inhibition of cell wall synthesis and is mediated through Bactocill binding to penicillin binding proteins (PBPs). Bactocill is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

 

Bactocill for patients

 

Bactocill Interactions

Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided.

 

Bactocill Contraindications

A history of a hypersensitivity (anaphylactic) reaction to any penicillin is a contraindication.

 

Additional information about Bactocill

Bactocill Indication: Used in the treatment of resistant staphylococci infections. Mechanism Of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Bactocill inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Bactocill interferes with an autolysin inhibitor. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Oxacillin Synonyms: Oxacillin Sodium Drug Category: Anti-Bacterial Agents; Penicillins Drug Type: Small Molecule; Approved Other Brand Names containing Oxacillin: Bactocill; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: 94.2 +/- 2.1% (binds to serum protein, mainly albumin) Biotransformation: Not Available Half Life: 20 to 30 minutes Dosage Forms of Bactocill: Solution Intramuscular Injection, solution Intravenous bolus Injection, solution Intravenous drip Capsule Oral Chemical IUPAC Name: (2S,5R,6R)-3,3-dimethyl-6-[(5-methyl-3-phenyl1,2-oxazole-4-carbonyl)amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical Formula: C19H19N3O5S Oxacillin on Wikipedia: https://en.wikipedia.org/wiki/Oxacillin Organisms Affected: Enteric bacteria and other eubacteria