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Apo-Trifluoperazine: Full Drug Profile

Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026

Apo-Trifluoperazine - General Information

A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic.

 

Pharmacology of Apo-Trifluoperazine

Apo-Trifluoperazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Apo-Trifluoperazine has not been shown effective in the management of behaviorial complications in patients with mental retardation.

 

Apo-Trifluoperazine for patients

 

Apo-Trifluoperazine Interactions

No information provided.

 

Apo-Trifluoperazine Contraindications

A known hypersensitivity to phenothiazines, comatose or greatly depressed states due to central nervous system depressants and, in cases of existing blood dyscrasias, bone marrow depression and pre-existing liver damage.

 

Additional information about Apo-Trifluoperazine

Apo-Trifluoperazine Indication: For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation. Mechanism Of Action: Apo-Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Trifluoperazine Synonyms: Not Available Drug Category: Antipsychotics; Antiemetics; Phenothiazines Drug Type: Small Molecule; Approved Other Brand Names containing Trifluoperazine: Apo-Trifluoperazine; Eskazine; Eskazinyl; Fluoperazine; Jatroneural; Modalina; Novo-Trifluzine; PMS Trifluoperazine; Stelazine; Stelazine Concentrate; Stellazine; Synklor; Terfluzine; Trazine; Trifluoperazin; Trifluoperazina; Trifluoperazine Dihydrochloride; Trifluoperazine HCl; Trifluoperazine Hydrochloride; Trifluoromethylperazine; Trifluoroperazine; Trifluoroperazine Dihydrochloride; Trifluoroperazine Hydrochloride; Trifluperazine; Triflurin; Trifluroperizine; Triftazin; Triftazine; Triperazine; Triphtazin; Triphtazine; Triphthasine; Triphthazine; Triphthazine Dihydrochloride; Tryptazine; Tryptazine Dihydrochloride; Absorption: Not Available Toxicity (Overdose): Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness. Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Apo-Trifluoperazine: Tablet Oral Syrup Oral Chemical IUPAC Name: 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine Chemical Formula: C21H24F3N3S Trifluoperazine on Wikipedia: https://en.wikipedia.org/wiki/Trifluoperazine Organisms Affected: Humans and other mammals