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Amsidine: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Amsidine - General Information

Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.

 

Pharmacology of Amsidine

Amsidine is an aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.

 

Amsidine for patients

 

Amsidine Interactions

 

Amsidine Contraindications

Avoid using with patients suffering bone marrow depression

 

Additional information about Amsidine

Amsidine Indication

For treatment of acute myeloid leukaemia.

Mechanism Of Action
Amsidine binds to DNA through intercalation and external binding. It has a base specificity for A-T pairs. Rapidly dividing cells are two to four times more sensitive to amsacrine than are resting cells. Amsidine appears to cleave DNA by inducing double stranded breaks. Amsidine also targets and inhibits topoisomerase II. Cytotoxicity is greatest during the S phase of the cell cycle when topoisomerase levels are at a maximum.
Generic Name
Amsacrine
Synonyms
Acridinyl Anisidide; M-AMSA; MAMSA
Drug Category
Antineoplastic Agents
Drug Type
Small Molecule; Approved
Other Brand Names containing Amsacrine
Amsidine; Amsidyl; Amsine; AMSA P-D;
Absorption
Poorly absorbed
Toxicity (Overdose)
Symptoms of overdose include nausea and vomiting, diarrhea, some cardiotoxicity (rarely).
Protein Binding
96-98%
Biotransformation
Extensive, primarily hepatic, converted to glutathione conjugate.
Half Life
8-9 hours
Dosage Forms of Amsidine
Liquid Intravenous
Chemical IUPAC Name
N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide
Chemical Formula
C21H19N3O3S
Organisms Affected
Humans and other mammals