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Amedel: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Amedel - General Information

An antineoplastic agent that acts by alkylation.

 

Pharmacology of Amedel

Amedel is an antineoplastic agent. Specifically it is a piperazine derivative with a chemical structure close to that of many DNA alkylating agents. Amedel has well documented clinical activity against polycythemia vera and essential thrombocythemia.

 

Amedel for patients

 

Amedel Interactions

 

Amedel Contraindications

Children under 15 years of age. Lactation. Bone marrow depression due to chemotherapy or X rays.

 

Additional information about Amedel

Amedel Indication: For the treatment of polycythaemia vera and refractory chronic myeloid leukaemia. Mechanism Of Action: The mechanism of action is uncertain but pipobroman is thought to alkylate DNA leading to disruption of DNA synthesis and eventual cell death. Drug Interactions: Acebutolol Antagonism Atenolol Antagonism Betaxolol Antagonism Bevantolol Antagonism Bisoprolol Antagonism Carteolol Antagonism Carvedilol Antagonism Esmolol Antagonism Labetalol Antagonism Metoprolol Antagonism Nadolol Antagonism Oxprenolol Antagonism Penbutolol Antagonism Pindolol Antagonism Practolol Antagonism Propranolol Antagonism Sotalol Antagonism Timolol Antagonism Food Interactions: Not Available Generic Name: Pipobroman Synonyms: Not Available Drug Category: Antineoplastic Agents Drug Type: Small Molecule; Approved Other Brand Names containing Pipobroman: Amedel; Vercyte; Absorption: Well absorbed from the GI tract. Toxicity (Overdose): Symptoms of overdose include hematologic toxicity, especially with chronic overdosage. Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Amedel: Not Available Chemical IUPAC Name: 3-bromo-1-[4-(3-bromopropanoyl)piperazin-1-yl]propan-1-one Chemical Formula: C10H16Br2N2O2 Pipobroman on Wikipedia: https://en.wikipedia.org/wiki/Pipobroman Organisms Affected: Humans and other mammals