Aerosporin

Aerosporin - General Information

Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.

Pharmacology of Aerosporin

Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant.

Aerosporin for patients

Aerosporin Interactions

No information provided.

Aerosporin Contraindications

This drug is contraindicated in persons with a prior history of hypersensitivity reactions to the polymyxins.

Additional information about Aerosporin

Aerosporin Indication: For treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.
Mechanism Of Action: Polymyxin B sulfate has a bactericidal action against almost all gram-negative bacilli except the Proteus group. Polymyxin B sulfate binds to and interferes with the permeability of the bacterial cytoplasmic membrane.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Polymyxin B Sulfate
Synonyms: Polymixin B sulfate; Polymyxin B sulfate salt; Polymyxin B sulphate
Drug Category: Anti-Bacterial Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Polymyxin B Sulfate: Aerosporin; Poly-RX;
Absorption: Not absorbed from the normal alimentary tract.
Toxicity (Overdose): Overdose can cause stomach pains, vomiting, and diarrhea.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Aerosporin: Powder, for solution Ophthalmic
Powder, for solution Intrathecal
Injection, solution Intramuscular
Injection, solution Intravenous drip
Chemical IUPAC Name: N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide; sulfuric acid
Chemical Formula: C56H100N16O17S
Polymyxin B Sulfate on Wikipedia: https://en.wikipedia.org/wiki/Polymyxin_B
Organisms Affected: Enteric bacteria and other eubacteria